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TranscriptomicsmiR-124 acts through coREST to control the onset of Sema3A sensitivity in navigating retinal growth cones
During axon pathfinding, growth cones commonly exhibit changes in sensitivity to guidance cues that follow a strict timetable, even in the absence of pathway feedback, implicating cell-intrinsic regulation. Cellular timer mechanisms, however, are poorly understood. Here we have investigated microRNA...
ORGANISM(S): Xenopus laevis 
2011-12-12 | E-GEOD-33444 | biostudies-arrayexpress
TranscriptomicsIllumina microarray experiment on LSD1 deletion ES cell with Lsd1Lox/Δ3 and Lsd1Δ3/Δ3
Lysine specific demethylase 1 (LSD1), which demethylates mono- and di- methylated histone H3-Lys4 as part of a complex including CoREST and histone deacetylases (HDAC), is essential for embryonic development in the mouse beyond e6.5 days. Here, we demonstrate that LSD1 expression and therefore funct...
ORGANISM(S): Mus musculus 
2010-12-06 | E-GEOD-21131 | biostudies-arrayexpress
ProteomicsCoRest’s acetylation acts as a temporal gate for activity-dependent transcription, limiting behavioral flexibility in Drosophila
In this project, to identify the proteins interacting with Rpd3 in the Drosophila mushroom body, the tandem affinity-purification(TAP) was performed. After in-solution digestion, the purified protein complex was analyzed by LC-MS/MS analysis using Orbitrap velos pro. PTM analysis was also performed...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2020-12-07 | PXD021294 | JPOST Repository
ProteomicsCoREST Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity
Epigenetic mechanisms tightly regulate gene expression at the chromatin level and have recently been found to colocalize with the splicing machinery during active transcription; however, the precise functional consequences of these interactions are uncertain. Here, we identify unique interactions of...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD056700 | Pride
Melanoma Corest Rna splicing Cryo-em Immunotherapy Neoantigens 
ProteomicsDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradationDisease-associated KBTBD4 mutations in medulloblastoma elicit neomorphic ubiquitylation activity to promote CoREST degradation
E3 ubiquitin ligases of the Cullin RING Ligase (CRL) family assemble into multiprotein complexes to diversify substrate adaptors and ensure selectivity in substrate engagement for degradation. Here we show a novel mechanism whereby mutations in substrate adaptors can drive neo-substrate degradation ...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD031683 | Pride
Medulloblastoma Kbtbd4 Ubiquitin Corest Epigenetic remodelling 
ProteomicsProximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation
Lysine specific demethylase 1 (LSD1/KDM1A) regulates gene expression as part of the CoREST complex, along with co-repressor of REST (CoREST) and histone deacetylase 1 (HDAC1). CoREST is recruited to specific genomic loci by components of the core complex and numerous transient interactions with chro...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-11-03 | PXD017344 | Pride
Embryonic stem cell Differentiation Bioid 
UnknownCoREST is an integral component of the CoREST- human histone deacetylase complex.
Not available
S-EPMC29278 | biostudies-literature
UnknownEndocrine resistance and breast cancer plasticity are controlled by CoREST.
Not available
S-EPMC9707522 | biostudies-literature
UnknownEpigenetic Regulator CoREST Controls Social Behavior in Ants.
Not available
S-EPMC7444844 | biostudies-literature
UnknownTargeting the GFI1/1B-CoREST Complex in Acute Myeloid Leukemia.
Not available
S-EPMC6794713 | biostudies-literature
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