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ProteomicsCalpain activity is regulated by a KCTD7–cullin 3 complex via non-degradative ubiquitination
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite inten...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038842 | Pride
Human Pasef Calpain 
ProteomicsHuman_HeLa endogenous KCTD7_IP-MS
endogenous KCTD7 were tagged by FLAG and then purified by TAP with FLAG M2 beads. The then sbujected to MS to ananlyze the interaction proteins with KCTD7.
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD028479 | Pride
Human Kctd7 Hela Ip-ms 
UnknownNovel mutations consolidate KCTD7 as a progressive myoclonus epilepsy gene.
Not available
S-EPMC3773914 | biostudies-literature
UnknownKctd7 deficiency induces myoclonic seizures associated with Purkinje cell death and microvascular defects.
Not available
S-EPMC9509889 | biostudies-literature
UnknownKCTD7 deficiency defines a distinct neurodegenerative disorder with a conserved autophagy-lysosome defect.
Not available
S-EPMC6295419 | biostudies-literature
UnknownProgressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function.
Not available
S-EPMC6702070 | biostudies-literature
UnknownKCTD7-related progressive myoclonic epilepsy: report of three Indian families and review of literature.
Not available
S-EPMC8918358 | biostudies-literature
UnknownKCTD7 mutations impair the trafficking of lysosomal enzymes through CLN5 accumulation to cause neuronal ceroid lipofuscinoses.
Not available
S-EPMC9348797 | biostudies-literature
UnknownCalpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.
Not available
S-EPMC10038992 | biostudies-literature
UnknownA homozygous mutation in KCTD7 links neuronal ceroid lipofuscinosis to the ubiquitin-proteasome system.
Not available
S-EPMC3397260 | biostudies-literature
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