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TranscriptomicsEffect of 10 or 25 days cortisol treatment on late gestation fetal septum
We have previously shown in sheep that 10 days of modest chronic increase in maternal cortisol result in fetal heart enlargement and Purkinje cell apoptosis. In subsequent studies in which we extended the duration of cortisol infusion (1mg/kg/d) to term, we found a dramatic incidence of stillbirth i...
ORGANISM(S): Ovis aries 
2014-08-07 | E-GEOD-54237 | biostudies-arrayexpress
TranscriptomicsThe Genomics of the Fetal Hypothalamic Cellular Response to Transient Hypoxia: Endocrine, Immune, and Metabolic Responses
Fetuses respond to transient hypoxia (a common stressor in utero) with cellular responses that are appropriate for promoting survival of the fetus. The present experiment was performed to identify the acute genomic responses of the fetal hypothalamus to transient hypoxia. Three fetal sheep were ex...
ORGANISM(S): Ovis aries 
2014-01-16 | E-GEOD-43371 | biostudies-arrayexpress
TranscriptomicsGenomics of the ovine fetal brain ontogeny during the last stage of gestation
Normal development in the brain requires temporal changes in gene expression. A better understanding of the genomics of the fetal brain during late gestation can help to improve our understanding of the molecular events that enable the newborn to survive extra-uterine life. The purpose of the prese...
ORGANISM(S): Ovis aries 
2014-06-30 | E-GEOD-50460 | biostudies-arrayexpress
TranscriptomicsTranscriptomics Responses to Hypoxia and Ketamine in Ovine Fetal Cerebral Cortex
Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. The chemoreceptor reflex that is responsible for this physiological response is dependent on glutamatergic neurotransmission which, in times of vig...
ORGANISM(S): Ovis aries 
2016-04-06 | E-GEOD-76110 | biostudies-arrayexpress
TranscriptomicsTranscriptomics of the Fetal Hypothalamic Response to Brachiocephalic Occusion and Estradiol Treatment
Estradiol (E2) is a well-known modulator of fetal neuroendocrine activity, and has been proposed as a critical endocrine signal readying the fetus for birth and postnatal life. To investigate the modulatory role of E2 on fetal stress responsiveness and the response of the fetal brain to asphyxic st...
ORGANISM(S): Ovis aries 
2014-07-01 | E-GEOD-52888 | biostudies-arrayexpress
TranscriptomicsGenomics of Estradiol-3-Sulfate Action in the Ovine Fetal Hypothalamus
In the fetal sheep during late gestation sulfoconjugated estrogens in plasma reach a concentration 40-100 times greater than unconjugated estrogens. The objective of the present study was to determine the genomics of estradiol-3-sulfate (E2S) action in the fetal brain. The hypothesis was that E2S st...
ORGANISM(S): Ovis aries 
2011-08-02 | E-GEOD-31184 | biostudies-arrayexpress
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