Sort   by:  
 Page size 
ProteomicsTRX1-enhanced CAR T cells retain their antitumor functions under pro-oxidative conditions
Immunotherapies with CAR-T cells achieve remarkable success, especially against B-cell malignancies. However, their activity against non-hematopoietic solid tumors is very limited. One central cause of this failure may be that a pro-oxidative tumor microenvironment can downmodulate the activation an...
ORGANISM(S): Homo sapiens (Human) 
2022-11-23 | PXD031073 | Pride
Car t cells Ros Immunosuppression Thioredoxin 1 Cancer immunotherapy Redox regulation 
UnknownCD38 in the pathobiology of cutaneous T-cell lymphoma and the potential for combination therapeutic intervention.
Not available
S-EPMC12055602 | biostudies-literature
ProteomicsIdentification of ELC interacting proteins in zebrafish heart
The essential myosin light chain (ELC) is part of the cardiac myosin motor regulating the contractility of the heart. Recently, we have demonstrated ELC phosphorylation to be responsible not only for basal maintenance of cardiac contractility, but also for the adaptation of sarcomere function to inc...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-07-24 | PXD016357 | Pride
Myosin light chain Elc Co-immunoprecipitation Phosphorylation 
ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins
The myosin light chain protein family consists of two classes, the regulatory myosin light chains (RLC) and the essential myosin light chains (ELC). Functionally, the MLC proteins are directly involved in sarcomeric activity and force transmission contributing to cardiac contractility. Besides regul...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD033908 | Pride
Cardiomyocytes Essential myosin light chains (elc) Phosphorylation Regulatory myosin light chains (rlc) 
ProteomicsAnalysis of myosin light chain migration pattern in 2D gels of human left ventricular proteins - proximity labeling
NIMA-related kinase 9 (NEK9) was identified to interact with the essential myosin light chain (ELC). To validate these findings ascorbate peroxidase (APEX) catalyzed proximity labeling (Hung et al. Nat Protoc. 2016) was performed. To do so, human ELC fused to APEX was overexpressed in HEK293 cells. ...
ORGANISM(S): Homo sapiens (Human) 
2022-07-24 | PXD034115 | Pride
Bioid Nek9 Elc 
TranscriptomicsTranscription profiling of maize inbred lines and inter-pool hybrids to investigate heterosis for plant height and consistency of gene expression
Loop-design (triangle design with the comparison of each triplet: hybrid + parent 1 and parent 2) and pairwise design (hybrid + parent 1, hybrid + parent 2) were used in the experiment.
Four inbred lines and their four inter-pool hybrids were hybridized respectively in two-colour chips experimen...
ORGANISM(S): Zea mays 
2006-08-17 | E-MEXP-764 | biostudies-arrayexpress
UnknownNatural history of infants with non-SCID T cell lymphopenia identified on newborn screen.
Not available
S-EPMC9756444 | biostudies-literature
UnknownPreclinical evaluation of anti-CD38 therapy in mature T-cell neoplasms.
Not available
S-EPMC10365939 | biostudies-literature
UnknownVirus-specific T-cell therapy to treat BK polyomavirus infection in bone marrow and solid organ transplant recipients.
Not available
S-EPMC7686882 | biostudies-literature
UnknownVirus-specific T cells for adenovirus infection after stem cell transplantation are highly effective and class II HLA restricted.
Not available
S-EPMC8525242 | biostudies-literature
Sort   by:  
 Page size