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ProteomicsAuxin Response Factor 6 and 8 LC-MS
The phytohormone auxin plays a pivotal role in promoting fruit initiation and growth upon fertilization in flowering plants. Upregulation of auxin signaling by genetic mutations or exogenous auxin treatment can induce seedless fruit formation from unpollinated ovaries, termed parthenocarpy. Recent s...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Nicotiana benthamiana 
2025-03-27 | PXD051232 | Pride
Arabidopsis Lc-ms O-glcnacylation Fucosylation 
TranscriptomicsRNAi knock down of the DNA-repair enzyme and transcriptional co-activator APE1 in human HeLa cells
Transcriptional profiling was done following APE1/Ref1 silencing using conditional gene expression knockdown by RNA interference (RNAi) technology in HeLa cell lines. APE1 is a DNA-repair enzyme and transcriptional co-activator. Knockdown leads to cell-growth arrest, apoptosis and impairment in the ...
ORGANISM(S): Homo sapiens 
2009-02-02 | E-MEXP-1315 | biostudies-arrayexpress
TranscriptomicsAPE1 knock-in
APE1/Ref-1 protects cells from oxidative stress by acting as a central enzyme in base excision repair pathways of DNA lesions and through its independent activity as a redox transcriptional co-activator. To dissect between redox- and DNA-repair-mediated effects, here we performed transcription profi...
ORGANISM(S): Homo sapiens 
2011-10-01 | E-MEXP-2941 | biostudies-arrayexpress
UnknownRelA Is an Essential Target for Enhancing Cellular Responses to the DNA Repair/Ref-1 Redox Signaling Protein and Restoring Perturbated Cellular Redox Homeostasis in Mouse PDAC Cells.
Not available
S-EPMC8988139 | biostudies-literature
UnknownIn vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer.
Not available
S-EPMC10749280 | biostudies-literature
UnknownAntitumor Activity and Mechanistic Characterization of APE1/Ref-1 Inhibitors in Bladder Cancer.
Not available
S-EPMC6844258 | biostudies-literature
UnknownA phase I study targeting the APE1/Ref-1 redox signaling protein with APX3330: first clinical agent targeting APE1/Ref-1 in cancer.
Not available
S-EPMC12857578 | biostudies-literature
UnknownThe redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.
Not available
S-EPMC3929656 | biostudies-literature
UnknownKnock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function.
Not available
S-EPMC3192867 | biostudies-literature
UnknownPrediction and Classification of Alzheimer's Disease Based on Combined Features From Apolipoprotein-E Genotype, Cerebrospinal Fluid, MR, and FDG-PET Imaging Biomarkers.
Not available
S-EPMC6805777 | biostudies-literature
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