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TranscriptomicsPurified human leukocyte subtype DNA methylation profiles
The objective of the study was to identify differentially methylated regions of DNA (DMRs) that distinguish human leukocyte subtypes, and hence serve as biomarkers for those immune cell types. This file contains Illumina Infinium HumanMethylation27 BeadChip data for human leukocyte subtypes that wer...
ORGANISM(S): Homo sapiens 
2012-11-05 | E-GEOD-39981 | biostudies-arrayexpress
TranscriptomicsMesothelioma integrative genomics: DNA methylation
Integrated profiling of somatic molecular alterations present in tumors is necessary to further our understanding of the tumorigenic process. We investigated the potential relationships between gene copy number alterations and DNA methylation profiles in a case series of pleural mesotheliomas (n=23)...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-GEOD-20989 | biostudies-arrayexpress
TranscriptomicsNon-small-cell lung tumor and normal lung tissue methylation
Using paired tumor and non-tumor lung tissues from 47 individuals we identified common changes in DNA methylation associated with the development of non-small cell lung cancer. Pathologically normal lung tissue taken at the time of cancer resection was matched to tumorous lung tissue and together we...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-27902 | biostudies-arrayexpress
TranscriptomicsDNA methylation distinguishes pathologically normal human tissues
Epigenetic control of gene transcription is critical for normal human development and cellular differentiation. While alterations of epigenetic marks such as DNA methylation have been linked to cancers and many other human diseases, interindividual epigenetic variation in normal tissues due to aging...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-19434 | biostudies-arrayexpress
TranscriptomicsGenetic and Epigenetic Somatic Alterations in Head and Neck Squamous Cell Carcinomas Are Globally Coordinated but Not Locally Targeted (GoldenGate methylation)
Solid tumors, including head and neck squamous cell carcinomas (HNSCC), arise as a result of genetic and epigenetic alterations in a sustained stress environment. Since it has been hypothesized that epigenetic alterations may act by providing the second carcinogenic hit in gene silencing, we sought ...
ORGANISM(S): Homo sapiens 
2010-06-23 | E-GEOD-20742 | biostudies-arrayexpress
TranscriptomicsLung adenocarcinoma and mesothelioma DNA methylation
Pathologic differentiation of tissue of origin in tumors found in the lung can be challenging, with differentiation of mesothelioma and lung adenocarcinoma emblematic of this problem. Indeed, proper classification is essential for determination of treatment regimen for these diseases, making accurat...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-16559 | biostudies-arrayexpress
TranscriptomicsIDH1 mutation defines methylation class and survival in human glioma
Astrocytoma, oligodendroglioma, oligoastrocytoma, and ependymoma are the main histologic subtypes of glioma. The molecular character of these subtypes has profound implications for understanding their causes and treatment. We describe the epigenetic landscape of these tumor types using novel DNA met...
ORGANISM(S): Homo sapiens 
2010-12-20 | E-GEOD-20395 | biostudies-arrayexpress
TranscriptomicsBreast tumor DNA methylation
Using primary breast tumors from 162 women from the Kaiser Division of Research Pathways Study and the Illumina GoldenGate methylation bead-array platform, we measured CpG loci associated with cancer-related genes 162 tumor specimens from the initial diagnostic biopsy were obtained from the KPNC tum...
ORGANISM(S): Homo sapiens 
2010-07-28 | E-GEOD-22290 | biostudies-arrayexpress
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