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TranscriptomicsEffect of microgravity on brain gene expression in mice
Changes in gravitational force such as that experienced by astronauts during space flight induce a redistribution of fluids from the caudad to the cephalad portion of the body together with an elimination of normal head-to-foot hydrostatic pressure gradients. To assess brain gene profile changes ass...
ORGANISM(S): Mus musculus 
2008-08-07 | E-GEOD-12312 | biostudies-arrayexpress
MetabolomicsIntegrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection
The metabolic effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on human blood plasma were characterized using multi-platform metabolic phenotyping with Nuclear Magnetic Resonance (NMR) spectroscopy and liquid chromatography-mass spectrometry (LC-MS). Quantitative mea...
2021-01-29 | MTBLS2014 | MetaboLights
TranscriptomicsGene Expression Profiling of Human Embryonic Neural Stem Cells and Dopaminergic Neurons from Adult Human Substantia Nigra
Our goal was to develop a list of genes that could be used effectively to highlight the genomic profiling of human embryonic neural stem cells (hENSCs), and to identify genes involved in the process of their differentiation to dopaminergic (DA) neurons. Our results showed that Agilent's Whole Human ...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-25931 | biostudies-arrayexpress
ProteomicsProteomic profiling of anterior pituitary of bull calves offered either a high or moderate plane of nutrition in early life
Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in bull calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in bulls, with the dynamics of gonadotropin pulsatility within the anterior pituitary ...
ORGANISM(S): Bos taurus (Bovine) 
2025-07-14 | PXD055940 | Pride
Nutrition Bovine Piturtary 
ProteomicsProteomic profiling of anterior pituitary of heifer calves offered either a high or moderate plane of nutrition in early life
Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in heifer calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in heifers, with the dynamics of gonadotropin pulsatility within the anterior pituitar...
ORGANISM(S): Bos taurus (Bovine) 
2024-07-04 | PXD042011 | Pride
Anterior pituitary Diet Heifer calves 
TranscriptomicsAscl1, Nurr1 and Lmx1 convert mouse and human fibroblasts into functional dopaminergic neurons without passing through an intermediate precursor state
Lineage-specific transcription factors, which drive cellular identity during embryogenesis, have been shown to convert cell fate when express ectopically in heterologous cells. Herein, we screened the key molecular factors governing the dopaminergic neuronal specification during brain development fo...
ORGANISM(S): Mus musculus 
2011-07-04 | E-GEOD-27174 | biostudies-arrayexpress
ProteomicsProteomic profiling of the hypothalamic arcuate nucleus of bull calves offered either a high or moderate plane of nutrition in early life
Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in bull calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in bulls, with the dynamics of the arcuate nucleus region of the hypothalamus, in part...
ORGANISM(S): Bos taurus (Bovine) 
2025-04-22 | PXD055939 | Pride
Nutrition Bovine Arcuate 
ProteomicsProteomic analysis underlying the impact of early life nutrition on the molecular control of testicular development in the young bull calf.
It has been established that enhanced early life nutrition progresses sexual development in the bull calf through neuroendocrine signalling via the hypothalamic-pituitary-testicular axis. However, the underlying molecular mechanisms regulating this process have not been fully elucidated. This study ...
ORGANISM(S): Bos taurus (Bovine) 
2022-08-30 | PXD031403 | Pride
Bull calf Nutrition Protein Early life Testes 
TranscriptomicsRNA-seq analysis of differential gene expression in muscle from Holstein Friesian bulls undergoing diet restriction and compensatory growth
The objective of this study was to examine changes in muscle gene expression of growing bulls during a period of dietary energy restriction followed by a period of subsequent realimentation and compensatory growth. Purebred Holstein Friesian bulls (n=20) were assigned to one of two feeding treatment...
ORGANISM(S): Bos taurus 
2015-09-04 | E-GEOD-64289 | biostudies-arrayexpress
TranscriptomicsSost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emergning as key regulatory proteins with great promise as therapeutic agents for bone disorders. Until recently Sost and its paralog Sostdc1 have been described as growth factors ...
ORGANISM(S): Mus musculus 
2013-08-17 | E-GEOD-44325 | biostudies-arrayexpress
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