Hereditary Leiomyomatosis and renal cell cancer (HLRCC) is caused by germline mutations of fumarate hydratase (FH) and subsequence accumulation of fumarate. Fumarate is known to activate the anti-oxidant response by KEAP1 succination and nuclear translocation of the transcription factor NRF2. The ac...
In order to examine the consequences of human miR-34a induction on the transcriptome, HCT116 cells (a colon cancer cell line) were infected with a retrovirus that produces miR-34a. Gene expression profiles were then monitored using Affymetrix microarrays. Affymetrix microarrays were used to examine...
