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GenomicsRegulation of the KEAP1/NRF2 oxidative stress response pathway by BRD4 in prostate and colorectal cancer
To identify genes regulated by BRD4 and to provide insight into new mechanisms de-regulated by BRD4, such as the response to oxidative stress, we integrated BRD4-binding regions with BRD4 gene expression data. For this analysis we performed BRD4 chromatin immunoprecipitation experiments and BRD4 kn...
ORGANISM(S): Homo sapiens 
2014-02-28 | E-GEOD-50491 | biostudies-arrayexpress
Genomics"Data Access Center Cancer Genomics Group"
Data Access Committee EGAC00001000030
EGAC00001000030 | EGA
TranscriptomicsThe bromodomain protein BRD4 regulates splicing during heat shock
During heat stress cyto-protective genes including heat shock proteins are transcriptionally up-regulated and post-transcriptional splicing is inhibited. In contrast, co-transcriptional mRNA-splicing is maintained. These factors closely resemble the proteotoxic stress response during tumor developme...
ORGANISM(S): Homo sapiens 
2016-09-07 | E-GEOD-73471 | biostudies-arrayexpress
UnknownCross-trait GWAS in COVID-19 and systemic sclerosis reveals novel genes implicated in fibrotic and inflammation pathways.
Not available
S-EPMC12107044 | biostudies-literature
UnknownFLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis.
Not available
S-EPMC9910569 | biostudies-literature
TranscriptomicsNOD2 and desease associated variant NOD2-L1007fsinsC dependent genomewide transcriptional regulation in stable Flp-In HEK cells
NOD2 is an intracellular receptor for the bacterial cell wall component muramyl dipeptide (MDP) and variants of NOD2 are associated with chronic inflammatory diseases of barrier organs e.g. Crohn disease, asthma and atopic eczema. It is known that activation of NOD2 induces a variety of inflammatory...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-22611 | biostudies-arrayexpress
UnknownIdentification of Mechanisms by Which Genetic Susceptibility Loci Influence Systemic Sclerosis Risk Using Functional Genomics in Primary T Cells and Monocytes.
Not available
S-EPMC10953390 | biostudies-literature
UnknownGWAS loci associated with Chagas cardiomyopathy influences DNA methylation levels.
Not available
S-EPMC8580254 | biostudies-literature
UnknownGenomic loss of HLA alleles may affect the clinical outcome in low-risk myelodysplastic syndrome patients.
Not available
S-EPMC6319343 | biostudies-literature
UnknownEpigenome-Wide Comparative Study Reveals Key Differences Between Mixed Connective Tissue Disease and Related Systemic Autoimmune Diseases.
Not available
S-EPMC6693476 | biostudies-literature
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