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UnknownUsing iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome.
Not available
S-EPMC3517299 | biostudies-literature
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20242 | biostudies-arrayexpress
TranscriptomicsHuman Aging-associated DNA Hypermethylation Occurs Preferentially at Bivalent Chromatin Domains
There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery c...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20236 | biostudies-arrayexpress
ProteomicsInternalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Internalization of therapeutic antibodies into Dendritic cells as a risk factor for immunogenicity" by Michel Siegel, Anna-Lena Bolender, Axel Ducret, Johannes Fraidling, Katha...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-26 | MSV000095695 | MassIVE
UnknownPerception of residents on the impacts of beach tourism: The case of Nungwi village in Zanzibar, Tanzania.
Not available
S-EPMC10658275 | biostudies-literature
MetabolomicsMolecular characterization of firefly nuptial gifts: a multi-omics approach sheds light on postcopulatory sexual selection
Postcopulatory sexual selection is recognized as a key driver of reproductive trait evolution, including the machinery required to produce endogenous nuptial gifts. Despite the importance of such gifts, the molecular composition of the non-gametic components of male ejaculates and their interactions...
2016-12-22 | MTBLS362 | MetaboLights
ProteomicsElucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay
The appended raw files, csv files and other documents were deposited in the public domain in support for the publication "Elucidation of B-cell specific drug immunogenicity liabilities via a novel ex vivo assay" by Cary M Looney, Axel Ducret, Guido Steiner, Karen Dernick, Katharina Hartman, Michel S...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-02-19 | MSV000097151 | MassIVE
TranscriptomicsChromatin immunoprecipitation of key transcriptional regulators, RNA polymerase II and histone methylation in mouse and human liver to measure binding at regulatory regions of homologous genes
To identify experimentally both conserved and evolving aspects of transcriptional regulation, we have measured the binding of key transcriptional regulators, RNA polymerase II and histone methylation in mouse and human liver at regulatory regions of homologous genes. As expected, the set of genes f...
ORGANISM(S): Homo sapiens 
2008-05-08 | E-TABM-144 | biostudies-arrayexpress
Metabolomics,MultiomicsGNPS Kava enzyme expression in Nicotiana benthamiana
The key enzymes of the kavalactone biosynthetic pathway from Piper methysticum were heterologuously expressed using agrobacterium infiltration in Nicotiana benthamiana. In addition, an isotopically labeled substrate, cinnamic acid-d6, was injected into the Nicotiana plants. Related to this study: Pl...
ORGANISM(S): Nicotiana Benthamiana (ncbitaxon:4100) 
2021-07-29 | MSV000087906 | GNPS
ProteomicsSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain
A role for the type I transmembrane trafficking receptor SORLA in reducing Aβ levels has been well-established, however, virtually nothing is known with respect to whether and how SORLA can potentially affect tau pathology. Here, we show that transgenic SORLA upregulation (SORLA TG) can reverse path...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-24 | PXD056276 | Pride
Tauopathy Alzheimer’s disease Tau Plexin Semaphorin Sorla Tau pathology 
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