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TranscriptomicsGene expression data from mouse postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. We measured the timing of gene expression changes in the brains of two species of mice throughout postnatal development. Mus musculus and Mus spretus mice were br...
ORGANISM(S): Mus musculus 
2009-03-09 | E-GEOD-11528 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [Ago2_IP]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-39227 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [miRNA transfection]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35620 | biostudies-arrayexpress
TranscriptomicsGene expression changes during primate postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain...
ORGANISM(S): Macaca mulatta 
2009-03-09 | E-GEOD-11512 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Macaca mulatta 
2012-12-20 | E-GEOD-35621 | biostudies-arrayexpress
TranscriptomicsEvolution of human-specific microRNA miR-941 [cerebellum gene expression]
miRNA-mediated gene expression silencing has previously been shown to be important for a variety of physiological and pathological processes. Here, we have explored the role of one bona fide human-specific miRNA (miR-941) in evolution of the human-specific expression and function. Using combination ...
ORGANISM(S): Homo sapiens 
2012-12-20 | E-GEOD-35619 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression and regulation in human, chimpanzee, and macaque brain
Among other factors, changes in gene expression on the human evolutionary lineage have been suggested to play an important role in the establishment of human-specific phenotypes. However, the molecular mechanisms underlying these expression changes are largely unknown. Here, we have explored the rol...
ORGANISM(S): Homo sapiens 
2011-10-17 | E-GEOD-26545 | biostudies-arrayexpress
TranscriptomicsLarge-scale multi-species survey of metabolome and lipidome
This dataset was generated with the goal of comparative study of gene expression in three brain regions and two non-neural tissues of humans, chimpanzees, macaque monkeys and mice. Using this dataset, we performed studies of gene expression and gene splicing evolution across species and search of ti...
ORGANISM(S): Macaca mulatta 
2014-05-30 | E-GEOD-49379 | biostudies-arrayexpress
TranscriptomicsEstimating accuracy of absolute gene expression measurement by RNA-Seq and microarrays with proteomics
Microarrays revolutionized biological research by enabling gene expression comparisons on a transcriptome-wide scale. Microarrays, however, do not estimate absolute expression level accurately. At present, high throughput sequencing is emerging as an alternative methodology for transcriptome studies...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-13744 | biostudies-arrayexpress
TranscriptomicsWidespread Expression of piRNA-like Molecules in Somatic Tissues
Piwi-interacting RNA (piRNA) are small RNA abundant in the germline across animal species. In fruit flies and mice, piRNA were implicated in maintenance of genomic integrity by transposable elements silencing. Outside of the germline, piRNA have only been found in Drosophila ovarian follicle cells. ...
ORGANISM(S): Mus musculus 
2011-06-01 | E-GEOD-27369 | biostudies-arrayexpress
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