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ProteomicsMolecular alterations elicited by chronic exposure to cigarette smoke and chewing tobacco in oral keratinocytes
Tobacco is mainly consumed in two different forms (smoking and chewing) that vary in their composition and methods of intake. Despite being the leading cause of oral cancer, the molecular mechanisms resulting in malignancy upon tobacco exposure are yet to be fully elucidated. We therefore sought to ...
ORGANISM(S): Homo sapiens (Human) 
2019-11-08 | PXD007127 | Pride
Chronic exposure Orbitrap fusion Carcinogenesis High-throughput Smoking 
UnknownInactivation of ATM/ATR DNA damage checkpoint promotes androgen induced chromosomal instability in prostate epithelial cells.
Not available
S-EPMC3525593 | biostudies-literature
UnknownCOMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis.
Not available
S-EPMC10111822 | biostudies-literature
UnknownExo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions.
Not available
S-EPMC3319278 | biostudies-literature
UnknownAnticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.
Not available
S-EPMC6742860 | biostudies-literature
UnknownhSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex.
Not available
S-EPMC3061066 | biostudies-literature
ProteomicsChronic exposure to chewing tobacco induces metabolic reprogramming and cancer stem cell-like properties in esophageal epithelial cells
Tobacco in its smoke and smokeless form are major risk factors for ESCC (esophageal squamous cell carcinoma). However, molecular alterations associated with smokeless tobacco exposure are poorly understood. In the Indian subcontinent, tobacco is predominantly consumed in chewing form. An understandi...
ORGANISM(S): Homo sapiens (Human) 
2019-11-11 | PXD013396 | Pride
Cancer stem cells Chewing tobacco Esophageal cancer Metabolic reprogramming 
UnknownIsolation of full-length ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype.
Not available
S-EPMC21549 | biostudies-literature
UnknownUV-induced hyperphosphorylation of replication protein a depends on DNA replication and expression of ATM protein.
Not available
S-EPMC34578 | biostudies-literature
UnknownA new non-catalytic role for ubiquitin ligase RNF8 in unfolding higher-order chromatin structure.
Not available
S-EPMC3365417 | biostudies-literature
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