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ProteomicsSystematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation
In this study, we systematically integrated proteome and acetyl proteome (acetylome) approaches to investigate the characteristics of renal proteins in a CaOx crystal rat model. We aimed to understand the pathogenesis of kidney calculi and delineate the landscape of acetylation within kidney calculi...
ORGANISM(S): Rattus norvegicus (Rat) 
2026-02-09 | PXD050342 | Pride
Kidney calculi  acetylation  proteomics 
TranscriptomicsKidney Stone Induces Developmental Stage-specific Alterations in Gene Expression
OBJECTIVES: Kidney stone diseases are common in premature infants, but the underlying molecular and cellular mechanisms are not fully defined. We carried out a prospective observational study using microarray analysis to identify factors that may be crucial for the initiation and progression of ston...
ORGANISM(S): Mus musculus 
2010-01-13 | E-GEOD-18160 | biostudies-arrayexpress
ProteomicsIntegrated proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats
We conducted a calculi rat model, applied for an integrated proteomic and transcriptomic analysis to characterize the distinct gene expression profiles in calculi oxalate stone formation and its related kidney injury. Six distinct gene clusters were identified according to the consistency of transcr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD039169 | Pride
Calcium oxalate  kidney stone  proteomics  transcriptomics  urolithiasis 
ProteomicsProteomic analysis of urine and stone matrix of patients with kidney calculi
Proteins have been extracted from kidney calculi with SDS buffer. Proteins were seperated by 1D-SDS-PAGE and stained with coomassie. Each gel lane was cut into 5 (or 6) pieces. Proteins were digested in gel with trypsin. Tryptic peptides were analysed by nanoLC-MS/MS on an ion trap instrument (6340 ...
ORGANISM(S): Homo sapiens (Human) 
2016-07-11 | PXD000302 | Pride
Inflammation Kidney stone Fibrosis Biomarker 
ProteomicsCharacterizations of HSP90-interacting complex in renal cells using tandem affinity purification and its potential role in kidney stone formation
Heat shock protein 90 (HSP90) is a highly abundant molecular chaperone that interacts with many other intracellular proteins to regulate various cellular processes. However, compositions of the HSP90-interacting complex remain underinvestigated. This study thus aimed to characterize such complex in ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-12-17 | MSV000083252 | MassIVE
TranscriptomicsTranscription profiling of mouse KO Clcn5-/- model for Dents disease in kidney, bone and intestine
Mutations in ClC-5 cause Dent's disease, a disorder associated with low molecular weight proteinuria, hyperphosphaturia and kidney stones. ClC-5 is a Cl /H+-exchanger predominantly expressed in the kidney, where it facilitates the acidification of proximal tubular endosomes. The reduction in proxima...
ORGANISM(S): Mus musculus 
2006-06-13 | E-MEXP-495 | biostudies-arrayexpress
UnknownUse of thiazide diuretics for the prevention of recurrent kidney calculi: a systematic review and meta-analysis.
Not available
S-EPMC7048029 | biostudies-literature
UnknownSystematic proteomics analysis of lysine acetylation reveals critical features of renal proteins in kidney calculi formation.
Not available
S-EPMC12851463 | biostudies-literature
UnknownRisk factors for deterioration of renal function after percutaneous nephrolithotomy in solitary kidney patients with staghorn calculi.
Not available
S-EPMC7658125 | biostudies-literature
UnknownProteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats.
Not available
S-EPMC10024419 | biostudies-literature
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