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TranscriptomicsTimecourse RNA-seq of kidney organoid development in control and WT1-knockout iPSCs
Absence of WT1 during kidney organoid development from human induced pluripotent stem cells (iPSCs) induces hallmarks of Wilms tumorigenesis. To define underlying transcriptional alterations and similarities to human patients, we performed timecourse RNA-seq of kidney organoid development from contr...
ORGANISM(S): Homo sapiens 
2021-08-01 | E-MTAB-9957 | biostudies-arrayexpress
ProteomicsProteomic analysis of kidney organoid supernatant during TNFa stimulation
Kidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic dynamics. However, their proteome has not been analyzed so far. Here, we analyzed the organoid proteome after treatment of organoids with 5ng/mL TNFalpha for 24h and 48h compare...
ORGANISM(S): Homo sapiens (Human) 
2023-05-12 | PXD029696 | Pride
Tnfalpha Cytokine Shotgun lc ms/ms Human kidney organoids Tnfa 
ProteomicsProteome analysis of kidney organoid cells during TNFa stimulation
Kidney organoids are a valuable and innovative model to understand genetic diseases, kidney development and transcriptomic dynamics. However, their proteome has not been analyzed so far. Here, we analyzed the organoid proteome after treatment of organoids with 5ng/mL TNFalpha for 24h and 48h compare...
ORGANISM(S): Homo sapiens (Human) 
2023-05-12 | PXD029718 | Pride
Tnfalpha Cytokine Shotgun lc ms/ms Human kidney organoids Tnfa 
ProteomicsKidney Organoids treated with TNFa at 5 ng/mL and 50ng/mL for 24h and 48h
This dataset serves as comparison for PXD029718 using a different organoid differentiation protocol – as requested by reviewers. Kidney organoids are a promising model to study kidney disease, but use is constrained by limited knowledge of their functional protein expression profile. We aimed to def...
ORGANISM(S): Homo sapiens (Human) 
2023-05-12 | PXD040812 | Pride
Human organoids kidney 
ProteomicsProteomic Profiling of Kidney Organoids in Extended Culture Conditions
We conducted a global proteomics analysis on kidney organoids at three distinct culture time points: day 22, day 33, and day 38. Our objective wasto investigate the impact of extended culture, beyond the standard differentiation endpoint of day 21, on the organoid protein expression profile.
ORGANISM(S): Homo sapiens (Human) 
2025-10-28 | PXD057360 | Pride
Proteomics Kidney organoids Extended culture Renal disease modeling 
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
GenomicsComparative analysis of kidney organoid and adult human kidney single cell and single nucleus transcriptomes
Comparative analysis of kidney organoid and adult human kidney single cell and single nucleus transcriptomes
PRJNA484783 | ENA
GenomicsGene expression profiling of human iPSC kidney organoid-derived epithelium
Gene expression profiling of human iPSC kidney organoid-derived epithelium
PRJNA419735 | ENA
GenomicsImmune Response of Transplanted Kidney Tissues Assembled from Organoid Building Blocks
Immune Response of Transplanted Kidney Tissues Assembled from Organoid Building Blocks
PRJNA1015229 | ENA
GenomicsSequencing of an organoid biobank for childhood kidney cancers that captures disease and tissue heterogeneity.
Kidney tumors are among the most common solid tumors in children, comprising several distinct subtypes differing in many aspects, including cell-of-origin, genetics, and pathology. Pre-clinical cell models capturing the disease heterogeneity are currently lacking. Here, we describe the first pediatr...
EGAS00001003853 | EGA
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