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ProteomicsThe protein complex of kinesin motor KIF1C and its hereditary spastic paraplegia associated mutant G102A
Regulated local translation, RNA transport and protein localization are critical for spatio-temporal gene expression in neurons. The localization of mRNA and subsequent local protein synthesis contribute to neuronal functions like synaptogenesis, synapse pruning, axon guidance, axonal regeneration a...
ORGANISM(S): Homo sapiens (Human) 
2023-12-28 | PXD037387 | Pride
Hereditary spastic paraplegia Kif1c Neuronal cells 
ProteomicsPTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surf...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD013939 | Pride
Autoinhibition Ptpn21 Hook3 Kif1c 
GenomicsThe kinesin KIF1C transports APC-dependent mRNAs to cell protrusions
The kinesin KIF1C transports APC-dependent mRNAs to cell protrusions
PRJNA677869 | ENA
TranscriptomicsThe kinesin KIF1C transports APC-dependent mRNAs to cell protrusions
Transcriptome analysis of specific mRNA interacting with KIF1C-GFP in HeLa Cells. RNA localization and local translation are involved in a wide range of cellular functions. In mammals, a class of mRNAs localize to cytoplasmic protrusions in an APC dependent manner, with important roles during cell m...
ORGANISM(S): Homo sapiens 
2020-11-13 | GSE161316 | GEO
UnknownCrosstalk between KIF1C and PRKAR1A in left atrial myxoma.
Not available
S-EPMC10349109 | biostudies-literature
UnknownForce generation of KIF1C is impaired by pathogenic mutations.
Not available
S-EPMC9631238 | biostudies-literature
UnknownThe kinesin KIF1C transports APC-dependent mRNAs to cell protrusions.
Not available
S-EPMC8594469 | biostudies-literature
UnknownPTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
Not available
S-EPMC6584639 | biostudies-literature
UnknownKIF1C facilitates retrograde transport of lysosomes through Hook3 and dynein.
Not available
S-EPMC11470034 | biostudies-literature
UnknownPodosome-regulating kinesin KIF1C translocates to the cell periphery in a CLASP-dependent manner.
Not available
S-EPMC4265736 | biostudies-literature
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