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ProteomicsPTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport
The kinesin-3 KIF1C is a fast organelle transporter implicated in the transport of dense core vesicles in neurons and the delivery of integrins to cell adhesions. Here we report the mechanisms of autoinhibition and release that control the activity of KIF1C. We show that the microtubule binding surf...
ORGANISM(S): Homo sapiens (Human) 
2019-06-24 | PXD013939 | Pride
Autoinhibition Ptpn21 Hook3 Kif1c 
ProteomicsThe role of ptpn21 in hematopoietic stem cells
To identify the downstream substrate/effector that mediates Ptpn21 function. We applied comprehensive phosphoproteomics analysis with Lin- cells isolated from Ptpn21-/- and Ptpn21+/+ mice. The analysis revealed many pTyr sites on molecules associated with cytoskeleton. Additionally, we present a lis...
ORGANISM(S): Mus Musculus 
PXD011381 |
GenomicsEffects of overexpression of PTPN21 on gene expression of Jurkat cells
Effects of overexpression of PTPN21 on gene expression of Jurkat cells
PRJNA1068044 | ENA
TranscriptomicsEffects of overexpression of PTPN21 on gene expression of Jurkat cells
Acute Lymphoblastic Leukemia (ALL) is a malignant disease characterized by the abnormal growth of immature lymphocytes. The high resistance to chemotherapy drugs and frequent recurrence contribute to low long-term survival in ALL patients. Presently, PTPN21 is associated with cancer development. Our...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE253979 | GEO
UnknownPtpn21 Controls Hematopoietic Stem Cell Homeostasis and Biomechanics.
Not available
S-EPMC6450721 | biostudies-literature
UnknownLoss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis.
Not available
S-EPMC11619687 | biostudies-literature
UnknownPTPN21 and Hook3 relieve KIF1C autoinhibition and activate intracellular transport.
Not available
S-EPMC6584639 | biostudies-literature
UnknownStructural analysis of PTPN21 reveals a dominant-negative effect of the FERM domain on its phosphatase activity.
Not available
S-EPMC10901363 | biostudies-literature
UnknownPTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway.
Not available
S-EPMC12043166 | biostudies-literature
UnknownPTPN21 Overexpression Promotes Osteogenic and Adipogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells but Inhibits the Immunosuppressive Function.
Not available
S-EPMC6907062 | biostudies-literature
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