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ProteomicsComparative proteome research in a zebrafish model for Vanishing White Matter disease
Vanishing white matter (VWM) disease is a genetic leukodystrophy leading to severe neurological disease and early death. VWM is caused by bi-allelic mutations in any of the five genes encoding the subunits of the eukaryotic translation factor 2B (EIF2B). Although previous studies are being attempted...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2021-09-10 | PXD023933 | Pride
Vanishing white matter disease Eif2b3 Comparative proteomics Slc1a4 
ProteomicsCharacterization of protein dynamics after alpha-amanitin exposure in hepatoma cells
Alpha-amanitin (α-AMA) is a cyclic peptide and is one of the most lethal mushroom amatoxins found in Amanita phalloides. α-AMA is known to cause hepatotoxicity through RNA polymerase II inhibition, which acts in RNA and DNA translocation. To investigate the toxic signature of α-AMA beyond known mech...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD018702 | Pride
Tric Alpha-amanitin Hepatotoxicity Comparative quantitative proteomics 
ProteomicsCharacterization of complement C3 as a marker of alpha-amanitin toxicity by comparative secretome profiling
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they represent the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be used to discover toxic mechanisms ...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD038016 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
ProteomicsCharacterization of hepatocytes secretomes after alpha-amanitin exposure by quantitative proteomics
In the human body, proteins secreted into peripheral blood vessels are known as the secretome, and they serve as a representation of the physiological or pathological status of cells. The unique response of cells to toxin exposure can be confirmed via secretome analysis, which can be applied to disc...
ORGANISM(S): Homo sapiens (Human) 
2024-05-23 | PXD036476 | Pride
Alpha-amanitin  toxic mushroom  secretomes  exposure marker  complement component 3 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035817 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
ProteomicsCharacterization of RAS/RAF/ERK signal cascade as a novel regulating factor in alpha-amanitin-induced liver injury
The well-known hepatotoxicity mechanism resulting from alpha-amanitin (-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from -AMA have not yet been fully ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035758 | Pride
Alpha-amanitin  toxic mushroom  acute liver failure  global phosphoproteome  ras/raf/erk signaling pathway 
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