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TranscriptomicsGlobal gene expression profiling of spontaneous mesotheliomas in F344N rats
Aged male Fischer 344/N rats are prone to developing spontaneous peritoneal mesotheliomas, which arise predominantly from the tunica vaginalis of the testes. A definitive cause for the predominance of this neoplasm in F344/N rats is unknown. Investigation of the molecular alterations that occur in s...
ORGANISM(S): Rattus norvegicus 
2013-09-06 | E-GEOD-47581 | biostudies-arrayexpress
TranscriptomicsThe Apple Flavonoid Phloretin Inhibits Escherichia coli O157:H7 Biofilm Formation and Ameliorates Colon Inflammation in Rat
Pathogenic biofilms have been associated with persistent infections due to high resistance to antimicrobial agents while commensal biofilms often fortify host immune system. Hence, controlling biofilm formation of both pathogenic bacteria and commensal bacteria is important in bacteria-related dise...
ORGANISM(S): Escherichia coli 
2011-11-22 | E-GEOD-28144 | biostudies-arrayexpress
TranscriptomicsMEF2D binding sites in rat hippocampal neurons
We analyzed the binding profiles of MEF2D, a member of MEF2 family transcription factors, in rat hippocampal neurons. Keywords: ChIP-chip We used custom-designed rat genome tiling array manufactured by Nimblegen Systems, Inc . This array contains probes that represent the following rat genomic regi...
ORGANISM(S): Rattus norvegicus 
2010-05-06 | E-GEOD-13551 | biostudies-arrayexpress
TranscriptomicsCharacterization of changes in global genes expression in the distal colon of loperamide-induced constipation SD rats in response to the laxative effects of Liriope platyphylla
In order to characterize the changes in global gene expression in the distal colon of constipated SD rats in response to the laxative effects induced by aqueous extract of Liriope platyphylla (AEtLP) including isoflavone, saponin, oligosaccharide, succinic acid and hydroxyproline, total RNA extracte...
ORGANISM(S): Rattus norvegicus 
2014-10-04 | E-GEOD-62041 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat peritoneal mesotheliomas following treatment with o-nitrotoluene or bromochloracetic acid
This study was performed to characterize the gene expression profile of rat peritoneal mesothelioma (RPM) formation following treatment of Fischer 344 rats with o-nitrotoluene (o-NT) or bromochloracetic acid (BCA). Experiment Overall Design: Four mesotheliomas from o-NT-treated rats and four mesot...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-4682 | biostudies-arrayexpress
TranscriptomicsExpression profiling of microRNA and mRNA on hepatic inflammation in high-fat induced murine model
The goal of this study was to identify and characterize of miRNA in the regulation of inflammatory responses of high-fat induced inflammation mouse model. In this study, we established a mouse model of high-fat-diet-induced inflammation to gain understanding on the biological functions deregulated ...
ORGANISM(S): Mus musculus 
2015-06-22 | E-GEOD-59042 | biostudies-arrayexpress
TranscriptomicsHypoxia transcriptome sequencing of blind mole rat (BMR, Spalax galili) and rat (Rattus norvegicus)
Deep sequencing of mRNA from Spalax galili and Rattus norvegicus Total RNAs were isolated from the brain of female BMRs under various oxygen concentrations (3%, 6%, 10%, 14%, and 21%) for 6 hours. We also got RNAs from the brain of rats under 6%, 10%, 14%, and 21% oxygen conditions.
ORGANISM(S): Nannospalax galili 
2014-06-05 | E-GEOD-49485 | biostudies-arrayexpress
TranscriptomicsGene expression profile of A549 cells from tissue of 4D model predicts poor prognosis in lung cancer patients
Tumor microenvironment plays an important role in regulating cell growth and metastasis. Recently we developed an ex vivo lung cancer model (4D) that forms perfusable tumor nodules on a lung matrix that mimics human lung cancer histopathology and protease secretion pattern. We compared the gene ex...
ORGANISM(S): Homo sapiens 
2013-09-16 | E-GEOD-45142 | biostudies-arrayexpress
TranscriptomicsSplicing function of mitotic regulators links R-loop mediated DNA damage to tumor cell killing
We discovered that two mitotic regulators, BuGZ and Bub3, involved in splicing regulation during interphase 8 samples from primary Human foreskin fibroblast cells (HFFs) , 12 samples from TOV21G cells. Control siRNA. BuGZ siRNA or Bub3 siRNA were transfected for 48 h before sample collection. Cells ...
ORGANISM(S): Homo sapiens 
2015-04-11 | E-GEOD-67770 | biostudies-arrayexpress
TranscriptomicsMPSS profiling of embryonic gonad and primordial germ cells
We used the MPSS technology to uncover gene expression profiling in a greater depth in the early embryonic gonads and primordial germ cells (PGCs) in the chicken. Total numbers of sequenced signatures were 1,012,533 and 995,676 for the PGCs and gonad. Using a false discovery rate cut-off of 0.05, we...
ORGANISM(S): Gallus gallus 
2007-02-28 | E-GEOD-5909 | biostudies-arrayexpress
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