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TranscriptomicsIL-10 from intestinal macrophages prevents excessive innate immune responses to bacteria by limiting IL-23 synthesis
Innate immune responses must be regulated in the intestine to prevent excessive inflammation. Here, using gene reporter mice, we show that a subset of mouse colonic macrophages constitutively produced the anti-inflammatory cytokine IL-10. In mice infected with Citrobacter rodentium, which is consid...
ORGANISM(S): Mus musculus 
2015-05-12 | E-GEOD-58677 | biostudies-arrayexpress
TranscriptomicsIL-33 induces a hypo-responsive human mast cell phenotype
Interleukin-33 (IL-33) is elevated in afflicted tissues of patients with mast cell-dependent chronic allergic diseases. Based on its acute effects on mouse mast cells (MCs), IL-33 is thought to play a role in the pathogenesis of allergic disease through MC activation. However, the manifestations of ...
ORGANISM(S): Mus musculus 
2013-02-06 | E-GEOD-39382 | biostudies-arrayexpress
TranscriptomicsPathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma
Polymorphisms in the interleukin-4 receptor ? chain (IL-4R?) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R? has been associated with severe asthma, especially i...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-18010 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human IL-9R+ T helper cells in presence of recombinant IL-9 against untreated control
To study the effect of paracrine interleukin-9 (IL-9) on T helper cells, we incubated IL-9R+ T helper cells isolated from blood (5 samples) and skin (3 samples) with or without IL-9 for 12h and the transcriptome was analyzed by bulk RNA-seq.
ORGANISM(S): Homo sapiens 
2022-10-31 | E-MTAB-12204 | biostudies-arrayexpress
TranscriptomicsIL-37 protects against obesity-induced inflammation and insulin resistance
Cytokines of the IL-1 family are important modulators of obesity-induced inflammation and the development of systemic insulin resistance. Here, we report that IL-37, a newly-described antiinflammatory member of the IL-1 family, affects obesity-induced inflammation and insulin resistance. IL-37 trans...
ORGANISM(S): Mus musculus 
2015-05-18 | E-GEOD-58952 | biostudies-arrayexpress
TranscriptomicsIL-2 regulated genes in scurfy CD4+ T-cells
The goal of the study was to identify the genes which are regulated by Interleukin-2 in the CD4+ T cells of the scurfy mice during regulatory T-cell deficiency. Scurfy (Sf) mice bear a mutation in the forkhead box P3 (Foxp3) transcription factor, lack regulatory T-cells (Treg), develop multi-organ i...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-23398 | biostudies-arrayexpress
MetabolomicsMetabolomics-Driven Discovery of an Introduced Species and Two Malaysian Piper betle L. Variants
The differences in pungency of 'sirih' imply the probable occurrence of several variants of Piper betle L. in Malaysia. However, the metabolite profiles underlying the pungency of the different variants remain a subject of further research. The differences in metabolite profiles of selected M...
2022-03-21 | MTBLS2585 | MetaboLights
Unknownp-Coumaric Acid Nanoparticles Ameliorate Diabetic Nephropathy via Regulating mRNA Expression of KIM-1 and GLUT-2 in Streptozotocin-Induced Diabetic Rats.
Not available
S-EPMC9785963 | biostudies-literature
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
TranscriptomicsMonopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
The segregation of maternal centromeres away from the paternal ones during the first division of meiosis depends on the attachment of sister kinetochores to microtubules emanating from the same spindle pole. In budding yeast monopolar attachment requires the recruitment to kinetochores of a protein ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-4792 | biostudies-arrayexpress
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