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ProteomicsUnveiling orphan receptor-like kinases in plants: novel client discovery using high-confidence library predictions in the Kinase–Client (KiC) assay
Plants are remarkable in their ability to adapt to changing environments, with receptor-like kinases (RLKs) playing a pivotal role in perceiving and transmitting environmental cues into cellular responses. Despite extensive research on RLKs from the plant kingdom, the function and activity (i.e., th...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-03-25 | PXD047713 | Pride
Phosphopeptides P2k1 In vitro screening Protein kinase Deep learning 
ProteomicsIdentifying receptor kinase substrates using an 8,000 peptide kinase client library enriched for conserved phosphorylation sites
In eukaryotic organisms, protein kinases regulate diverse protein activities and signaling pathways through phosphorylation of specific protein substrates. Isolating and characterizing kinase substrates is vital for defining downstream signaling pathways. The Kinase Client (KiC) assay is an in vitro...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-02-26 | PXD056072 | Pride
Candidates P2k1 Phosphopeptide 
ProteomicsDirect Coupling of Nod Factor Signaling to Vesicular Trafficking Initiates Legume Nodulation
Legume–rhizobium symbiosis requires coordinated receptor signaling and membrane trafficking to initiate infection thread formation in root hairs. Here, we identify the soybean Qa-SNARE GmSYNTAXIN111a (GmSYP111a), a close paralog of the cytokinesis-associated protein KNOLLE, as a critical regulator o...
ORGANISM(S): Glycine max Arabidopsis thaliana (Mouse-ear cress) 
2026-07-10 | PXD068787 | Pride
Legume–rhizobium symbiosis Clathrin-mediated endocytosis Kinase client assay Infection thread initiation Soybean nodulation Phosphorylation Snare complex regulation 
UnknownUnveiling orphan receptor-like kinases in plants: novel client discovery using high-confidence library predictions in the Kinase-Client (KiC) assay.
Not available
S-EPMC11021772 | biostudies-literature
ProteomicsAnalysis of protein phosphorylation in response to the ATP treatment in Arabidopsis thaliana
The project intended to reveal protein phosphorylation patterns in Arabidopsis thaliana in response to ATP. For this purpose, Arabidopsis thaliana plants, including WT, ATP receptor mutants (p2k1, p2k2, and double mutant p2k1/p2k2), and P2K1 overexpression plants, were treated with ATP or buffer (as...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
MSV000095888 | MassIVE
ProteomicsProteomic profiling by array of tyrosine kinase activity in metastatic malignant melanoma from human tissue specimens
Tyrosine kinase activity profiling of metatstatic malignant melanoma and normal skin tissue samples was performed using peptide kinase arrays. All samples were run in triplicates with and withouth inhbitor PLX4032 and Sutent Malate in order to identify how tyrosine kinases responds to kinase inhibit...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1245 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of liver from wild type vs glycerol kinase knockout mice to understand the molecular pathogenesis of GKD
Glycerol kinase deficiency (GKD) is an X-linked inborn error of metabolism with metabolic and neurologic crises. Liver shows the highest level of glycerol kinase (GK) activity in humans and mice. Absence of genotype-phenotype correlations in patients with GKD indicate the involvement of modifier gen...
ORGANISM(S): Mus musculus 
2007-12-12 | E-GEOD-3843 | biostudies-arrayexpress
UnknownIdentifying Receptor Kinase Substrates Using an 8000 Peptide Kinase Client Library Enriched for Conserved Phosphorylation Sites.
Not available
S-EPMC11952801 | biostudies-literature
TranscriptomicsKinase activity profiling of human locally advanced rectal cancer samples
Locally advanced rectal cancer characterized by multiplex kinase activity profiling
ORGANISM(S): Homo sapiens 
2010-08-05 | E-TABM-913 | biostudies-arrayexpress
ProteomicsBead-based kinase phosphorylation profiling identifies SRC as a therapeutic target in glioblastoma
Here we describe a bead-based method capable of profiling tyrosine kinase phosphorylations in a multiplexed, high-throughput and low-cost manner. This approach allows for the discovery of tyrosine kinase-activating events, even when the DNA sequence is wild-type. In an effort to pilot the establishm...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-13808 | biostudies-arrayexpress
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