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TranscriptomicsTranscription profiling of mouse embryonic fibroblasts from wild type and IRAK-4 kinase dead animals stimulated with IL-1b for different durations to identify IRAK-4 kinase-dependent IL-1b response genes.
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Though regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. In order to investigate the role ...
ORGANISM(S): Mus musculus 
2007-11-15 | E-GEOD-6789 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of SIK2 regulated genes and pathways
Identification of SIK2 regulated genes and pathways after SIK2 knock-down and overexpression of a wild-type and kinase-dead SIK2. The hypothesis is that SIK2 regulated gene expression via CREB1 Total RNAs were obtained after SIK2 gene was knocked down with siRNA and after a wild-type SIK2 or a kinas...
ORGANISM(S): Homo sapiens 
2015-01-12 | E-GEOD-45711 | biostudies-arrayexpress
ProteomicsDEAD box RNA helicases are pervasive protein kinase interactors and activators
DEAD box (DDX) RNA helicases are a large family of ATPases, many of which have unknown functions. There is emerging evidence that besides their role in RNA biology, DDX proteins may stimulate protein kinases. To investigate if protein kinase-DDX interaction is a more widespread phenomenon, we conduc...
ORGANISM(S): Homo sapiens (Human) 
2024-03-10 | PXD043289 | Pride
Kinase activators Rna helicases Interactome 
TranscriptomicsTranscription profiling of Trypanosoma brucei DHH1 DEAD:DQAD mutant from pLEW100 for 24 hours
Induction of the expression of the DHH1 DEAD:DQAD mutant from pLEW100 for 24 hours (thus, M-1 24 hours
Tetracycline). Uninduced cells were used as control.
ORGANISM(S): Trypanosoma brucei 
2010-01-01 | E-MEXP-2026 | biostudies-arrayexpress
TranscriptomicsAnalysis of Apoptosis-associated Tyrosine Kinase (AATK) function
Expression of AATK and kinase-dead AATK in the TREx inducible system (T-REx-293 cells).
ORGANISM(S): Homo sapiens 
2023-03-01 | E-MTAB-11198 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse bone marrow macrophages from WT and IRAK4 kinase
IRAK-4 is an essential component of the signal transduction complex downstream of the IL-1- and Toll-like receptors. Though regarded as the first kinase in the signaling cascade, the role of IRAK-4 kinase activity versus its scaffold function is still controversial. In order to investigate the role ...
ORGANISM(S): Mus musculus 
2008-10-20 | E-GEOD-9037 | biostudies-arrayexpress
GenomicsMediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA
CCCTC-binding factor (CTCF) is a DNA-binding protein that plays important roles in chromatin organization, though the mechanism by which CTCF carries out these functions is not fully understood. Recent studies show that CTCF recruits the cohesin complex to insulator sites and that cohesin is require...
ORGANISM(S): Homo sapiens 
2010-11-16 | E-GEOD-24126 | biostudies-arrayexpress
TranscriptomicsExpression data from Flt3L-derived bone marrow dendritic cells from WT or Clec9agfp/gfp mice treated or not with dead cells
DNGR-1 (CLEC9A) is expressed in CD8-like dendritic cells (DCs) and detects a ligand exposed on necrotic cells. We have characterized the transcripts that are induced in cultures of Flt3L-derived bone-marrow-derived WT or DNGR1-deficient DCs upon incubation with dead cells. Microarray analysis of the...
ORGANISM(S): Mus musculus 
2012-04-30 | E-GEOD-36435 | biostudies-arrayexpress
ProteomicsJin_Context_dependent_interactions_between_HSP90_and_kinase_clientele
This submission consists of the mass spectrometry raw files for the manuscript by Jin et al. (Mutational analysis of GSK3B protein kinase together with kinome-wide binding and stability studies suggest context-dependent recognition of kinases by the chaperone HSP90). This submission contains files f...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-01-06 | MSV000079445 | MassIVE
TranscriptomicsTranscription profiling of rat kidney iosgrafts from live or brain dead donors with samples taken before and after transplantation
The clinical results obtained with organ allografts from marginal or extended donors are less satisfactory over both the short-term and long-term than the outcome of grafting from living donors. Early postoperative graft function depends on several pretransplant factors, with the major donor influen...
ORGANISM(S): Rattus norvegicus 
2008-05-07 | E-GEOD-5104 | biostudies-arrayexpress
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