Sort   by:  
 Page size 
ProteomicsTemporal analysis of tear fluid proteome reveals critical corneal repair events after photorefractive surgery
The cornea is the transparent tissue at the forefront of the eye. Its outermost layer, the corneal epithelium, acts as a protective barrier for the ocular chamber. The cornea is avascular and its homeostasis relies on alternative sources to receive nutrients and growth factors, essential for maintai...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-10 | PXD067691 | Pride
Tear film Epithelium Wound healing Proteomic Cornea 
ProteomicsComparative analysis of tear proteomics in PAX6 mutant and control mice of both sexes before and after abrasion
Our team is working on aniridia, an autosomal dominant condition and has used a mouse model. The cornea, the eye’s first avascular and transparent optical surface, is covered by a stratified epithelium that constantly renews itself; any disruption compromises transparency and threatens vision. The t...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-01 | PXD070553 | Pride
Tear proteomics Wound healing Pax6 Aniridia 
ProteomicsPLAPAX6: Proteomic study of tears from patients with a PAX6 mutation
The cornea is the eye’s first optical surface, avascular and transparent, covered externally by a stratified epithelium that constantly renews itself. Disruption in this renewal compromises transparency, potentially leading to vision loss. The corneal surface is protected and nourished by the tear f...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD066455 | Pride
Pax6 Aniridia Tears proteomic 
ProteomicsLoss of tRNA uridine thiolation affects mRNA translation, protein production, and sulfur-compound metabolism in Arabidopsis
The uridine at position 34 of tRNA anticodon loops is always modified at variable levels depending on environmental conditions, but a function for this highly conserved modification has not been firmly established. Using Arabidopsis thaliana, we show that the thiolation of U34 is a prerequisite for ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-10-05 | PXD070279 | Pride
Sulfur Ctu2 mutation Trna epitranscriptomic networks Ribosome dynamic Codon optimality 
ProteomicsModeling the simultaneous dynamics of proteins in blood plasma and the cerebrospinal fluid in human in vivo
The analysis of protein dynamics or turnover in patients has the potential to reveal altered protein recycling such as in Alzheimer disease, and to provide informative data regarding drug efficacy, or certain biological processes. The observed protein dynamics in a solid tissue or a fluid is the net...
ORGANISM(S): Homo Sapiens 
2025-04-30 | PXD047851 | panorama
ProteomicsStable Isotope Labeling by Amino acid in Vivo (SILAV)
Intravenous administration of stable isotope labeled amino acid ((13)C6-leucine) to humans recently made it possible to study the metabolism of specific biomarkers in cerebrospinal fluid (CSF) and in plasma using targeted mass spectrometry (MS). This labeling approach could be of great interest for ...
ORGANISM(S): Homo Sapiens 
2025-11-15 | PXD046142 | panorama
Sort   by:  
 Page size