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ProteomicsGranulocyte-Colony Stimulating Factor reduces cocaine-seeking and downregulates glutamatergic synaptic proteins in medial prefrontal cortex
Abstract Background Psychostimulant use disorder is a major public health issue, and despite the scope of the problem there are currently no FDA approved treatments. There would be tremendous utility in development of a treatment that could help patients both achieve and maintain abstinence. Previou...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-01-28 | PXD019485 | Pride
Cocaine Glutamate Reinstatement Neuroimmune Granulocyte-colony stimulating factor 
TranscriptomicsCocaine-regulated expression of striatal microRNAs
We cataloged miRNA expression in the nucleus accumbens and at striatal synapses in control and chronically cocaine-treated mice. We identified cocaine-responsive miRNAs, synaptically-enriched and depleted miRNA families, and confirmed cocaine-induced changes in protein expression for several predict...
ORGANISM(S): Mus musculus 
2011-05-13 | E-GEOD-29261 | biostudies-arrayexpress
TranscriptomicsEffects of cocaine and withdrawal on the mouse nucleus accumbens transcriptome.
Genetic association studies, pharmacological investigations and analysis of mice-lacking individual genes have made it clear that Cocaine administration and Withdrawal have a profound impact on multiple neurotransmitter systems. The GABAergic medium spiny neurons of the nucleus accumbens (NAc) exhib...
ORGANISM(S): Mus musculus 
2013-01-10 | E-GEOD-43410 | biostudies-arrayexpress
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