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TranscriptomicsTranscription profiling of mouse WAP-SVT/t transgenic animals during breast cancer formation
Microarray studies revealed that as a first hit, SV40 T/t-antigen causes deregulation of 462 genes in mammary gland cells (ME-cells) of WAP-SVT/t transgenic animals. The majority of deregulated genes are cell-proliferation specific and Rb-E2F dependent, causing ME-cell proliferation and gland hyperp...
ORGANISM(S): Mus musculus 
2009-04-25 | E-GEOD-6246 | biostudies-arrayexpress
UnknownEchinacea/sage or chlorhexidine/lidocaine for treating acute sore throats: a randomized double-blind trial.
Not available
S-EPMC3351972 | biostudies-literature
TranscriptomicsTranscription profiling of human and mouse breast cancers
This SuperSeries is composed of the following subset Series:; GSE6581: Expression data from mammary glands of transgenic mice; GSE6596: Comparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes Experiment Overall Design: Refer to individua...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6772 | biostudies-arrayexpress
TranscriptomicsInfluence of alkyl-phospholipids on the gene expression profile of immortalized keratinocytes HaCaT
New alkyl-phospholipids (APLs) that are structurally derived from the platelet-activating factor are promising candidates for anticancer treatment. After the incorporation into cell membranes, APLs are able to interfere with a wide variety of key enzymes implicated in cell growth, motility, invasion...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-20722 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human colorectal cancer cell lines treated with O-glycan inhibitors generate aryl-glycans, induce apoptosis, and inhibit growth
Our studies provide direct evidence that O-glycosylation pathways play a role in the regulation of cell growth through apoptosis and proliferation pathways. Eight small molecular weight analogues of the GalNAc-alpha-1-O-serine/threonine structure based on 1-benzyl-2-acetamido-2- deoxy-alpha-O-D-gala...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12422 | biostudies-arrayexpress
TranscriptomicsExpression data from human NHL cell lines treated with agonistic antibodies
CD20 is a clinically validated target for Non-Hodgkin’s lymphomas and autoimmune diseases. Interactions of CD20 with the B cell receptor (BCR) and components of the BCR signaling cascade have been reported. In this study we show that antibodies against CD20 or activation of the BCR by specific antib...
ORGANISM(S): Homo sapiens 
2013-07-23 | E-GEOD-23394 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for breast cancer formation in mouse
We investigated the CNAs in a four stage tumorigenesis model. This model included copy number analyses in non-transgenic NMRI mice (normal) and in transgenic SVT/t mice: non-malignant hyperplastic mammary glands and breast cancers, as well as breast cancer derived cell lines. We focused our research...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-35873 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse primitive and maturing hematopoietic stem cells
Gene expression studies from hematopoietic stem cell (HSC) populations purified to variable degrees have defined a set of stemness genes. The present study describes the construction and comparative molecular analysis of l-phage cDNA libraries from highly purified primitive HSCs (PHSCs) which retain...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4391 | biostudies-arrayexpress
MetabolomicsEvaluation of sample preparation methods for NMR-based metabolomics of cow milk
The quality of milk metabolome analyzed by nuclear magnetic resonance (NMR) is greatly influenced by the way samples are prepared. Although this analytical method is increasingly used to study milk metabolites, a thorough examination of available sample preparation protocols for milk has not been re...
2019-06-13 | MTBLS623 | MetaboLights
TranscriptomicsComparison of gene expression data from human and mouse breast cancers: Identification of conserved breast tumor genes
The aim of our work was the comparison of human and mouse gene expression data and to identify a conserved breast tumor gene set. The results encourage the usefulness of transgenic mice as a model for human breast cancer formation and therapy. Keywords: Comparison of gene expression data The aim of ...
ORGANISM(S): Homo sapiens 
2007-01-12 | E-GEOD-6596 | biostudies-arrayexpress
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