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TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells, CD27 memory B-cells, polyclonal plasmablastic cells and human myeloma cell lines
Gene expression profiling of CD138 purified bone marrow plasma cells of healthy donors, CD27 memory B-cells, cultured ployclonal plasmablastic cells and cultured human myeloma cell lines. Samples from healthy donors have been re-used from ArrayExpress experiment E-MEXP-2360. Some of the myeloma cell...
ORGANISM(S): Homo sapiens 
2017-02-23 | E-MTAB-5212 | biostudies-arrayexpress
GenomicsRetrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro B cells
The establishment of distinct transcription programs during development is controlled by transcription factor networks acting in specific chromatin environments. The H3K9me3-specific histone methyltransferase Setdb1 impacts on transcriptional regulation by repressing both developmental genes and ret...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-77636 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human CD138 purified bone marrow plasma cells from patients with smoldering multiple myeloma
Gene expression profiling of CD138 purified bone marrow plasma cells of patients with smoldering multiple myeloma
ORGANISM(S): Homo sapiens 
2023-05-31 | E-MTAB-4743 | biostudies-arrayexpress
ProteomicsRadioproteomics stratifies molecular response to antifibrotic treatment in pulmonary fibrosis
Antifibrotic therapy with nintedanib is the clinical mainstay in the treatment of progressive fibrosing interstitial lung disease (ILD). High-dimensional medical image analysis, known as radiomics, provides quantitative insights into organ-scale pathophysiology, generating digital disease fingerprin...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-17 | PXD052594 | Pride
Interstitial lung disease Radiomics Proteomics Multiomics Imaging Lung fibrosis Nintedanib 
TranscriptomicsTranscription profiling of human testis, primary myeloma cell and normal tissue samples to identify novel cancer-testis genes
Cancer-testis (CT) antigens are attractive targets for immunotherapeutic strategies since they are aberrantly expressed in malignant cells and not, or in limited number, in somatic tissues, except germ cells. To identify novel CT genes in multiple myeloma, we used Affymetrix HG-U133 gene expression ...
ORGANISM(S): Homo sapiens 
2009-01-20 | E-MTAB-81 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human plasma cell samples from multiple myeloma patients
Samples in this series are pre-treatment bone marrow aspirates from multiple myeloma patients. Experiment Overall Design: Samples in this series are: Experiment Overall Design: 1. CD-138-selected plasma cells from bone marrow of patients with newly diagnosed multiple myeloma subsequently treated wit...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-2658 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of 5T33MM cells treated in vivo with quisinostat, decitabine or the combination.
Epigenetic modulating agents are under intense investigation for cancer therapy including multiple myeloma. In this study, we investigated the in vivo transcriptional response to epigenetic modulating agents in multiple myeloma using the 5T33MM model with the aim to identify potential clinical rele...
ORGANISM(S): Mus musculus 
2018-02-26 | E-MTAB-3178 | biostudies-arrayexpress
TranscriptomicsDeciphering myeloma risk loci by eQTL analysis
Recent genome-wide association studies have identified single nucleotide polymorphisms (SNPs) at 7 loci influencing multiple myeloma (MM) risk. We generated expression quantitative trait loci (eQTL) data on malignant plasma cells from two patient series (totaling 848) to fine map the risk loci assoc...
ORGANISM(S): Homo sapiens 
2014-12-09 | E-MTAB-2299 | biostudies-arrayexpress
TranscriptomicsCD3+ T-cells of B-cell chronic lymphocytic leukemia
Analysis of T-cells isolated from CD3+ T-cells of patients with B-cell chronic lymphocytic leukemia (B-CLL). In contrast to other types of cancers, the non-malignant T-cell compartment of B CLL patients is expanded. Results provide insights into the role of T-cells in B-CLL. Purified T-cells of B-CL...
ORGANISM(S): Homo sapiens 
2009-11-25 | E-GEOD-19147 | biostudies-arrayexpress
TranscriptomicsMicroarray profiling of polyploid macrophage progeny
To explore how bacterial lipoproteins (i.e. TLR2 ligands) increased macrophage ploidy via mitotic defects, we performed global analysis of cell cycle gene expression changes induced by bacterial lipoproteins. FSL-1 (Pam2CGDPKHPKSF) is a synthetic lipoprotein that represents the N-terminal part of th...
ORGANISM(S): Mus musculus 
2016-10-27 | E-MTAB-5085 | biostudies-arrayexpress
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