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Transcriptomicsc-Met confers protection against chronic liver tissue damage and fibrosis progression after bile-duct-ligation in mice
The HGF/c-Met system is an essential inducer of hepatocyte growth and proliferation. Although a fundamental role for the HGF receptor c-Met has been demonstrated in acute liver regeneration its cell specific role in hepatocytes during chronic liver injury and fibrosis progression has not been determ...
ORGANISM(S): Mus musculus 
2009-02-18 | E-GEOD-13992 | biostudies-arrayexpress
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
TranscriptomicsMurine colon: IL-10-/- versus BALB/c
MicroRNA profiling of mouse colonic tissue comparing severe colon pathology with mild and no pathology. Three condition experiment: BALB/c (No Pathology Control), IL-10-/- with Pathology = 1, IL-10-/- with Pathology > 3. Biological replicates were pooled RNA samples of 3 separate mice per condition...
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-31706 | biostudies-arrayexpress
MetabolomicsUrine Latin Square Spike-In for testing the NMR quantification tool, MetaboQuant
To test the quantification performance of MetaboQuant and other NMR quantification tools, a set of eight metabolites were added to replicates of a urine sample in varying concentrations. The metabolites were alanine, creatinine, histidine, betaine, acetate, phosphocreatine, β-hydroxybutyrate (BHBA) ...
2013-01-10 | MTBLS25 | MetaboLights
ProteomicsComprehensive analysis of C. glutamicum anaplerotic deletion mutants under defined D-glucose conditions
Wild-type C. glutamicum ATCC 13032 is known to possess two enzymes with anaplerotic (C4-directed) carboxylation activity, namely phosphoenolpyruvate carboxylase (PEPCx) and pyruvate carboxylase (PCx). On the other hand, C3-directed decarboxylation can be catalyzed by the three enzymes phosphoenolpyr...
ORGANISM(S): Corynebacterium glutamicum ATCC 13032 
2021-09-09 | PXD022622 | Pride
Methylcitrate cycle Phosphoenolpyruvate carboxykinase Corynebacterium glutamicum Oxaloacetate decarboxylase Pyruvate carboxylase Anaplerosis Malic enzyme Phosphoenolpyruvate carboxylase 
TranscriptomicsGlobal gene expression change in the cerebellum of Niemann-Pick disease type C mice with deletion of Ccl3 or Purkinje neuron-specific NPC1 rescue
Macrophage inflammatory protein 1alpha/CCL3 protein is a known pro-inflammatory cytokine that can mediate chemotaxis of monocytes and promote cell degranulation. Ccl3 gene expression is elevated in the CNS and visceral tissue of many lysosomal storage disorders. The deletion of Ccl3 in a mouse model...
ORGANISM(S): Mus musculus 
2012-04-16 | E-GEOD-36119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X to identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma
Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1sg/ml tetracycline treatment to induce the ...
ORGANISM(S): Homo sapiens 
2007-10-30 | E-GEOD-2700 | biostudies-arrayexpress
ProteomicsFinding New Drug Targets for Niemann Pick Type C Hepatic Disease Based On Proteomic Network Analysis
A significant area of rare diseases research is the investigation of druggable protein encoding genes that contribute to pathogenesis. Niemann Pick Type C (NPC) disease can be considered as a challenging one, among all rare diseases, because it has been associated with a poor prognosis and an unclea...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-23 | PXD026623 | Pride
Lc-ms Liver Hepatocytes Niemann pick type c Npc 
TranscriptomicsPRR7 is a novel NMDA-dependent inhibitor of c-Jun ubiquitination in neurons
Elevated c-Jun levels result in apoptosis and are evident in neurodegenerative disorders such as Alzheimer's disease and dementia and after global cerebral insults such as stroke and epilepsy. NMDA receptor (NMDAR) antagonists block c-Jun upregulation and prevent neuronal cell death following excito...
ORGANISM(S): Rattus norvegicus 
2014-10-25 | E-GEOD-62686 | biostudies-arrayexpress
UnknownCrystal and molecular structures of some phosphane-substituted cymantrenes [(C5H4X)Mn(CO)LL'] (X = H or Cl, L = CO, L' = PPh3 or PCy3, and LL' = Ph2PCH2CH2PPh2).
Not available
S-EPMC8491095 | biostudies-literature
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