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ProteomicsProteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg
Fertilization triggers release from meiotic arrest and initiates events that prepare for the ensuing developmental program. Protein degradation and phosphorylation are known to regulate protein activity during this process. However, the full extent of protein loss and phospho-regulation is still unk...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2017-11-29 | PXD006639 | Pride
Xenopus Egg Fertilization 
MetabolomicsGlycerol 3-phosphate phosphatase/PGPH-2 counters metabolic stress and promotes healthy aging via a glycogen sensing-AMPK-HLH-30-autophagy axis in C. elegans
Metabolic stress caused by excess nutrients accelerates aging. We recently demonstrated that the newly discovered enzyme glycerol-3-phosphate phosphatase (G3PP; gene Pgp), which operates an evolutionarily conserved glycerol shunt that hydrolyzes glucose-derived glycerol-3-phosphate to glycerol, coun...
2024-02-07 | MTBLS6847 | MetaboLights
TranscriptomicsComparison of the DNA methylation of bovine blastocysts and bovine sperm
DNA from expanded bovine blastocysts and bovine sperm were extracted then subjected to methylation-sensitive enzymatic digestion and LM-PCR enrichment before being hybridized onto a microarray. Two-condition experiment, bovine blastocysts (pools of 10) vs bovine sperm. Four biological replicates of ...
ORGANISM(S): Bos taurus 
2014-09-09 | E-GEOD-57709 | biostudies-arrayexpress
UnknownProteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg.
Not available
S-EPMC5740657 | biostudies-literature
TranscriptomicsDroplet barcoding for single cell transcriptomics applied to embryonic stem cells
Recently, RNA sequencing has achieved single cell resolution, but what is limiting is an effective way to routinely isolate and process large numbers of individual cells for in-depth sequencing, and to do so quantitatively. We have developed a droplet-microfluidic approach for parallel barcoding tho...
ORGANISM(S): Homo sapiens 
2015-05-20 | E-GEOD-65525 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome profiling of sigH overexpression in L. sakei
Comparison of L. sakei overexpressing sigH and wild type strain
ORGANISM(S): Lactobacillus sakei 
2012-01-01 | E-MEXP-3238 | biostudies-arrayexpress
UnknownOn the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development.
Not available
S-EPMC4776761 | biostudies-literature
Genomicsena-DATASET-NIBR-04-08-2016-14:28:22:169-118 - samples
Exome sequencing reads of two UFM individuals and their family members (totally 11 individuals) belonging to two different Fragile X families. Alignment files in BAM format are provided.
EGAD00001002276 | EGA
GenomicsExome-sequencing of two UFM individuals and their Fragile X family members.
Fragile X syndrome (FXS) is a monogenic neurodevelopmental disease often caused by a CGG triplet expansion in the 5’UTR of the FMR1 gene, which results in DNA methylation of the FMR1 promoter and its transcriptional silencing. Exceptional healthy individuals named "unmethylated full mutation (UFM)" ...
EGAS00001001737 | EGA
GenomicsNovartis-Cattolica UFM collaboration Data Access Committee
Data Access Committee EGAC00001000512
EGAC00001000512 | EGA
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