Sort   by:  
 Page size 
TranscriptomicsThe Anti-Aging and Tumor Suppressor Protein Klotho Affects Signaling Pathwaysin a Human Oligodendroglioma Cell Line
Klotho functions as an aging suppressor, which, in mice, extends lifespan when overexpressed and accelerates development of aging-like phenotypes when disrupted. Klotho is mainly expressed in brain and kidney and is secreted into the serum and CSF. We have previously shown that Klotho is reduced in ...
ORGANISM(S): Homo sapiens 
2014-06-09 | E-GEOD-51536 | biostudies-arrayexpress
ProteomicsExtrarenal α-klotho expression in human tissues
α-Klotho has emerged as a powerful regulator of the ageing process. To-date, the expression profile of α-Klotho in human tissues is unknown and its existence in some human tissue types is subject to much controversy. Objective: This is the first study to characterize system-wide tissue expression of...
ORGANISM(S): Homo sapiens (Human) 
2015-10-13 | PXD002775 | Pride
Human Prm Klotho Ontogeny 
ProteomicsExtrarenal ?-klotho expression in human tissues
?-Klotho has emerged as a powerful regulator of the ageing process. To-date, the expression profile of ?-Klotho in human tissues is unknown and its existence in some human tissue types is subject to much controversy. Objective: This is the first study to characterize system-wide tissue expression of...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080719 | MassIVE
ProteomicsHippocampal proteomic profiling following peripheral delivery of klotho fragment
We found that a klotho protein fragment (KL-F), administered peripherally, induced cognitive enhancement and neural resilience. Here we report a proteomic analysis of whole hippocampal homogenates from mice treated with vehicle or KL-F (10 µg/kg, i.p.) four hours prior to exploration in the small Y-...
ORGANISM(S): Mus musculus (Mouse) 
2017-08-09 | PXD007150 | Pride
Hippocampus Dia Swath Biognosys Klotho 
GenomicsKlotho inhibits neuronal senescence in human brain organoids
Klotho inhibits neuronal senescence in human brain organoids
PRJNA720649 | ENA
GenomicsKlotho suppresses colorectal cancer through modulation of the unfolded protein response
Klotho suppresses colorectal cancer through modulation of the unfolded protein response
PRJNA485062 | ENA
GenomicsTranscriptomic response to Klotho deficiency in the renal distal convolution
Transcriptomic response to Klotho deficiency in the renal distal convolution
PRJNA1035540 | ENA
TranscriptomicsActivity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis
Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function. Although highly expressed in specific areas of the brain, Klotho functions in the central nervous system remain unknow. Here, we show that cultured hippocampal neurons respond...
ORGANISM(S): Mus musculus 
2018-03-08 | GSE100046 | GEO
TranscriptomicsmicroRNA expression in various tissues of klotho-deficient and wild-type mice
The expression profiles of miRNAs in klotho-deficient and wild-type mice were examined by means of GenopalM-BM-.-MICM DNA chips. The data suggested that there was a difference in the expression of miRNAs between klotho-deficient and wild-type mice. Small RNA samples prevared from 5-week-old klotho-d...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-34531 | biostudies-arrayexpress
GenomicsTranscriptomics profiling reveals novel FGF23 targets in a Klotho-dependent and independent manner
Transcriptomics profiling reveals novel FGF23 targets in a Klotho-dependent and independent manner
PRJNA1045679 | ENA
Sort   by:  
 Page size