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ProteomicsThe composition and structure of the outer kinetochore KMN complex is conserved across Kingdoms
In eukaryotes, chromosome segregation during cell division requires attachment to the spindle, which is ensured by a large multi-protein structure called the kinetochore. The outer layer of the kinetochore attaches to the microtubules and is named after three of its components KNL1C, MIS12C, and NDC...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-11-17 | PXD062209 | Pride
Ap-ms Arabidopsis Kinetochore Kmn complex 
UnknownStructure of the human outer kinetochore KMN network complex.
Not available
S-EPMC11189301 | biostudies-literature
ProteomicsAn Mtw1 C terminal motif is cruical for cooperative outer kinetochore assembly in budding yeast
We employed chemical crosslinking and mass spectrometry on in vitro reconstituted outer kinetochore KMN network.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-09-30 | PXD011775 | Pride
Kmn Mtw1 Yeast Kinetochore 
UnknownThe composition and structure of the outer kinetochore KMN complex is conserved across kingdoms.
Not available
S-EPMC12595034 | biostudies-literature
UnknownStructure of the human KMN complex and implications for regulation of its assembly.
Not available
S-EPMC11189300 | biostudies-literature
ProteomicsAssembly and phospho-regulatory mechanisms of the budding yeast outer kinetochore KMN complex
Crosslinking of KMN outer kinetochore complex. During mitosis and meiosis kinetochores mediate interactions between chromosomes and spindle microtubules. Kinetochores are multi-megadalton protein complexes essential for chromosome segregation in all eukaryotes, however recent structural, functional,...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-03-16 | PXD072662 | Pride
Kinetochore Cl-ms Crosslinking 
UnknownMultiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
Not available
S-EPMC4298689 | biostudies-literature
UnknownCnn1 inhibits the interactions between the KMN complexes of the yeast kinetochore.
Not available
S-EPMC3438452 | biostudies-literature
UnknownDistinct organization and regulation of the outer kinetochore KMN network downstream of CENP-C and CENP-T.
Not available
S-EPMC4348146 | biostudies-literature
ProteomicsCross-linking mass spectrometry analyses of three different kinetochore protein complexes (KMN, NDC80C, MIS12C) using an MS-cleavable cross-linker, BuUrBu (DSBU)
In order to develop a simplified cross-linking mass spectrometry protocol, we applied one-step size-exclusion chromatography (SEC) for peptide purification after proteolysis with Lys-C and trypsin. Three benchmark protein complexes (KMN, NDC80C, MIS12C) from human kinetochore were cross-linked with ...
ORGANISM(S): Homo sapiens (Human) 
2019-04-01 | PXD010070 | Pride
Dsbu Q-exactive Cross-linking ms Buurbu Merox Human Kinetochore Protein complex Ms-cleavable cross-linker 
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