In eukaryotes, chromosome segregation during cell division requires attachment to the spindle, which is ensured by a large multi-protein structure called the kinetochore. The outer layer of the kinetochore attaches to the microtubules and is named after three of its components KNL1C, MIS12C, and NDC...
To explore the possible role of Nsd2 in kidney cancer, the gene expression profile of kisney tissues from KMN (Ksp-Cre; Myc OE/+; Nsd2 OE/+) and littermate KM (Ksp-Cre; Myc OE/+) mice was examined by RNA sequencing(RNA-Seq).
Crosslinking of KMN outer kinetochore complex. During mitosis and meiosis kinetochores mediate interactions between chromosomes and spindle microtubules. Kinetochores are multi-megadalton protein complexes essential for chromosome segregation in all eukaryotes, however recent structural, functional,...
