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TranscriptomicsLong-term adaptation to hypoxic conditions - Febit transcriptome analysis
Aspergillus fumigatus is an opportunistic, airborne pathogen causing invasive aspergillosis in immunocompromised patients. During the infection process A. fumigatus is challenged by hypoxic microenvironments occurring in inflammatory, necrotic tissue. To gain further insights into the adaptation mec...
ORGANISM(S): Aspergillus fumigatus 
2014-07-01 | E-MTAB-2699 | biostudies-arrayexpress
ProteomicsIdentification of proteomic markers in head and neck cancer using MALDI-MS Imaging, LC-MS/MS and IHC
Purpose The heterogeneity of squamous cell carcinoma tissue complicates diagnosis and an individualized therapy to a great extent. Therefore it is of utmost importance to spatially characterize this tissue heterogeneity and to identify appropriate biomarkers. Matrix assisted laser desorption/ionizat...
ORGANISM(S): Homo sapiens (Human) 
2018-11-14 | PXD009144 | Pride
Cancer Maldi-ms imaging Immunohistochemistry Biomarker Lc-ms/ms 
ProteomicsSurviving oxidative stress under iron starvation: an important lesson eminently learned by Aspergillus fumigatus in the human body
Aspergillus fumigatus has to cope with a combination of several stress types after colonisng the human body, and the interplay between the different stress responses can significantly influence the survival of this human pathogen during the invasion of the host organism. In this study, we examined h...
ORGANISM(S): Aspergillus fumigatus Af293 
2018-05-16 | PXD006250 | Pride
Proteomics Iron starvation Lc-ms Stress response Oxidative stress Aspergillus fumigatus Tandem mass tags 
ProteomicsIdentification of proteins interacting with cytoplasmic high-mobility group box 1 (HMGB1) during the hepatocellular response to ischemia reperfusion injury
Ischemia/reperfusion injury (IRI) occurs in liver transplantations and major resections and can lead to liver dysfunction. HMGB1 locates in nucleus of normal hepatocytes, but translocates to cytoplasm and the extracellular space during IRI. Although the functions of nuclear and extracellular HMGB1 a...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-03-10 | PXD003538 | Pride
2d-ge Hmgb1 Lc-ms Ischemia 
ProteomicsCreA phosphorylation sites are important for the regulation of carbon catabolite repression in filamentous fungi
Saprobic microorganisms, such as filamentous fungi of the genus Aspergillus, are of particular interest for biotechnological applications due to their natural capacity to secrete plant cell wall-degrading enzymes that are known as carbohydrate-active enzymes (CAZy). The presence of easily metaboliza...
ORGANISM(S): Emericella nidulans (Aspergillus nidulans) 
2021-02-18 | PXD018967 | Pride
Lc-ms Aspergillus nidulans Crea Carbon catabolite repression Phosphoproteomics 
ProteomicsRedox proteomic analysis reveals an important role for protein oxidative modifications in hypoxia adaptation of Aspergillus fumigatus
In the site of infection, the human fungal pathogen Aspergillus fumigatus faces dynamic changes in oxygen concentrations. The ability to survive in severely hypoxic environments during host invasion is one of important virulence traits of A. fumigatus. Therefore, investigation of hypoxia adaptation ...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2019-01-16 | PXD006822 | Pride
Lc-ms/ms Aspergillus fumigatus Redoxproteomics Hypoxia Ros 
ProteomicsIntegration of multilevel OMICs data based on the identification of regulatory modules from protein-protein interaction networks
Complex scientific experiments provide researchers with a wealth of data and knowledge from heterogeneous sources. Analyzed in its entirety, OMICs data provide a deep insight into the overall biological processes of organisms. However, the integration of data from different cellular levels (e.g., tr...
ORGANISM(S): Neosartorya fumigata (Aspergillus fumigatus) 
2018-10-25 | PXD008153 | Pride
Caspofungin Proteomics Lc-ms Aspergillus fumigatus Secretome 
ProteomicsImmune modulation by complement receptor 3 (CD18/CD11b) dependent human monocyte TGF-β1-transporting vesicles
Extracellular vesicles play an important role in human cellular communication. Here, we show that human and mouse monocytes release TGF-β1-transporting vesicles in response to the pathogenic fungus Candida albicans. Soluble beta-glucan from Candida albicans binds to complement receptor 3 (CR3, CD11b...
ORGANISM(S): Homo sapiens (Human) 
2020-04-22 | PXD015780 | Pride
Monocytes Mass spectrometry Extracellular vesicles Complement receptor 3 Tgf-β1 
ProteomicsComparative proteomic analysis to study the involvement of the Tor pathway in the human-pathogenic fungus Aspergillus fumigatus
The Tor kinase is one of the major regulatory nodes in a eukaryotic cell and until now, little is known about this kinase in filamentous fungi. Here, we analysed the Tor kinase in Aspergillus fumigatus, which is the most important airborne fungal pathogen of humans and the main causative agent of in...
ORGANISM(S): Aspergillus fumigatus CEA10 
2022-02-28 | PXD001601 | Pride
Proteomics Tor kinase Lc-ms/ms  tmt Fungi 
TranscriptomicsIntegrative phenotypic and transcriptomic validation of an alveolar-like macrophage model reveals early host–pathogen dynamics during Aspergillus fumigatus infection
The saprophytic mold Aspergillus fumigatus produces small (2-3 µm) airborne spores (conidia) that can reach the lung alveoli upon inhalation. There, they encounter the surfactant-rich environment of the alveolar epithelium and initiate swelling and germination. Primary alveolar macrophages are essen...
ORGANISM(S): Homo sapiens 
2026-10-02 | E-MTAB-17130 | biostudies-arrayexpress
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