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TranscriptomicsComparative transcriptome of S. aureus strains
We report the transcriptome profiles (RNA seq) of three different co-isolates of S.aureus that have been identified and isolated in both laboratory and infective scenarios. The transcriptome profiles were generated by deep sequencing and transcript levels assessed. For this the raw reads underwent q...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2014-10-13 | E-GEOD-49636 | biostudies-arrayexpress
TranscriptomicsComputational drug repositioning identifies niclosamide and tribromsalan as inhibitors of Mycobacterium tuberculosis and Mycobacterium abscessus
Tuberculosis (TB) is still a major global health challenge, killing over 1.5 million people each year, and hence, there is a need to identify and develop novel treatments for Mycobacterium tuberculosis (M. tuberculosis). The prevalence of infections caused by nontuberculous mycobacteria (NTM) is als...
ORGANISM(S): Mycobacterium tuberculosis 
2024-03-01 | E-MTAB-13761 | biostudies-arrayexpress
UnknownEffectiveness of a serious game addressing guideline adherence: cohort study with 1.5-year follow-up.
Not available
S-EPMC8008024 | biostudies-literature
TranscriptomicsDissecting the Mycobacterium bovis BCG response to macrophage infection to identify targets for anti-tuberculosis drug and vaccine discovery
New strategies are required to reduce the worldwide burden of tuberculosis. Intracellular survival and replication of Mycobacterium tuberculosis after macrophage phagocytosis is a fundamental step in the complex host-pathogen interactions that lead to granuloma formation and disease. Greater underst...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2 
2022-01-14 | E-MTAB-11107 | biostudies-arrayexpress
TranscriptomicsM. tuberculosis Rv3263 Knockout
We determine gene expression profile for the knockout of Rv3263 (DNA Methyltransferase) and compared to wildtype M. tuberculosis. Two RNA-Seq datasets are included: wildtype (H37Rv_SS1) and knockout (delta_Rv3263)
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2013-11-21 | E-GEOD-52551 | biostudies-arrayexpress
TranscriptomicsIdentification of antigens presented by MHC for vaccines against tuberculosis
The immune response against tuberculosis relies, at least in part, on CD4+ T cells. Protective vaccines require the induction of antigen-specific CD4+ T cells via mycobacterial peptides presented by MHC class-II in infected macrophages. We have purified MHC class-I and MHC-II peptides and analysed t...
ORGANISM(S): Mycobacterium tuberculosis variant bovis BCG 
2020-01-08 | E-MTAB-8057 | biostudies-arrayexpress
UnknownEvaluation of large-group lectures in medicine - development of the SETMED-L (Student Evaluation of Teaching in MEDical Lectures) questionnaire.
Not available
S-EPMC5563045 | biostudies-literature
TranscriptomicsTranscriptome analysis of M.tuberculosis using RNA-seq indicates WhiB6 repression of dormancy associated genes
Tuberculosis is an infectious disease, with latent infection with Mycobacterium tuberculosis (M.tb) affecting 1/3 of humanity. It can remain quiescent for long time, making eradication very difficult. To do so, M.tb need to carefully orchestrate its gene expression to survive immune response and sta...
ORGANISM(S): Mycobacterium tuberculosis CDC1551 
2013-09-18 | E-GEOD-40941 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
UnknownAn LDLR missense variant poses high risk of familial hypercholesterolemia in 30% of Greenlanders and offers potential of early cardiovascular disease intervention.
Not available
S-EPMC9577620 | biostudies-literature
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