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TranscriptomicsCellular aging can be monitored by DNA-methylation changes at specific CpG sites
Long-term culture associated changes need to be considered for quality control of cell preparations – especially in cellular therapy. Here we describe a simple method to track cellular aging based on continuous DNA-methylation changes at six specific CpG sites. This epigenetic signature can be used ...
ORGANISM(S): Homo sapiens 
2012-05-21 | E-GEOD-29661 | biostudies-arrayexpress
UnknownIs muscle and protein loss relevant in long-term fasting in healthy men? A prospective trial on physiological adaptations.
Not available
S-EPMC8718030 | biostudies-literature
UnknownLipidomics Reveals Seasonal Shifts in a Large-Bodied Hibernator, the Brown Bear.
Not available
S-EPMC6474398 | biostudies-literature
UnknownCardiomyocyte Protection by Hibernating Brown Bear Serum: Toward the Identification of New Protective Molecules Against Myocardial Infarction.
Not available
S-EPMC8322573 | biostudies-literature
TranscriptomicsGene expression profiles of induced pluripotent mesenchymal stromal cells [Affymetrix]
Reprogramming of somatic cells into induced pluripotent stem cells (iPSC) is an epigenetic phenomenon. We have reprogrammed mesenchymal stromal cells (MSC) from human bone marrow by retrovirus-mediated overexpression of OCT-3/4, SOX2, c-MYC, and KLF4. This series summarizes gene expression profiles ...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-38806 | biostudies-arrayexpress
TranscriptomicsMethylation Pattern of Human Dermal Fibroblasts
In this study, we have analyzed DNA methylation changes upon aging of human dermal fibroblasts by using the HumanMethylation27 BeadChip assessing 27,578 unique CpG sites. Cells were isolated from skin samples donated by young (6-23 years) and elderly (60-73 years) patients undergoing surgical interv...
ORGANISM(S): Homo sapiens 
2012-02-14 | E-GEOD-22595 | biostudies-arrayexpress
UnknownLimited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos).
Not available
S-EPMC6770786 | biostudies-literature
TranscriptomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (RNA-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59966 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for different passages of mesenchymal stem cells.
Cells in culture undergo replicative senescence and unequivocally stop proliferation after a limited number of cell divisions. In this study, we have expanded mesenchymal stem cells (MSC) from human adipose tissue and analyzed genetic and epigenetic sequels. The subpopulation of highly proliferative...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-GEOD-27135 | biostudies-arrayexpress
UnknownA new case report of severe mucopolysaccharidosis type VII: diagnosis, treatment with haematopoietic cell transplantation and prenatal diagnosis in a second pregnancy.
Not available
S-EPMC6238262 | biostudies-literature
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