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TranscriptomicsExcessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment
Background Identification of patients at risk of tuberculosis relapse following treatment would revolutionize clinical trials of new drugs and regimens and facilitate clinical management. The study aim was to determine whether tuberculosis patients who subsequently suffer relapse have different immu...
ORGANISM(S): Homo sapiens 
2015-09-10 | E-GEOD-67589 | biostudies-arrayexpress
MetabolomicsPhospholipid acyl chain diversity controls the tissue-specific assembly of mitochondrial cardiolipins

Cardiolipin (CL) is a phospholipid specific for mitochondrial membranes and crucial for many core tasks of this organelle. Its side chain configurations are tissue-specific, functionally important and generated via post-biosynthetic remodeling. However, this process lacks the necessary specificit...

2020-05-22 | MTBLS1446 | MetaboLights
TranscriptomicsTuberculosis patients blood gene expression through treatment
Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-31348 | biostudies-arrayexpress
UnknownEvaluation of Sporicidal Disinfectants for the Disinfection of Personal Protective Equipment During Biological Hazards.
Not available
S-EPMC7047094 | biostudies-literature
TranscriptomicsTuberculosis Patients Blood Gene Expression Through Treatment (cured and end-of-treatment patients)
Background Accurate assessment of treatment efficacy would facilitate clinical trials of new anti-tuberculosis drugs. TB patients exhibit altered peripheral immunity which reverts during successful treatment. We hypothesised that these changes could be observed in whole blood transcriptome profiles...
ORGANISM(S): Homo sapiens 
2012-08-09 | E-GEOD-36238 | biostudies-arrayexpress
TranscriptomicsDNA Methylation of gDNA from blood and bronchoalveolar lavage of tuburbulosis patients with and without type 2 diabetes via Illumina Infinium MethylationEPIC array
Tuberculosis (TB) remains a leading cause of illness and death globally. Type 2 diabetes (T2D) patients are more likely to become infected with Mycobacterium tuberculosis (M.tb). When they are infected, they are more likely to develop active TB disease and to present with more severe TB and those wh...
ORGANISM(S): Homo sapiens 
2025-12-14 | E-MTAB-16151 | biostudies-arrayexpress
ProteomicsTarget Landscape of Clinical Kinase Inhibitors
Here, we provide a comprehensive overview of the selectivity profiles of 242 kinase inhibitors currently in clinical trials. We screened available inhibitors against human protein kinases by using the Kinobead technology resulting in a drug matrix identifying the druggable kinome and related protein...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2018-01-12 | MSV000081932 | MassIVE
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