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TranscriptomicsWidespread targeted chromatin remodeling during the initial phase of somatic cell reprogramming [expression]
Despite rapid progress in characterizing transcription factor-driven reprogramming of somatic cells to an induced pluripotent stem (iPS) cell state, many mechanistic questions still remain. To gain insight into the earliest events in the reprogramming process, we systematically analyzed the transcri...
ORGANISM(S): Mus musculus 
2011-01-03 | E-GEOD-26096 | biostudies-arrayexpress
TranscriptomicsTargeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Homeobox (HOX) proteins and the receptor tyrosine kinase FLT3 are frequently highly expressed and mutated in acute myeloid leukemia (AML). Aberrant HOX expression is found in nearly all AMLs that harbor a mutation in the Nucleophosmin (NPM1) gene, and FLT3 is concomitantly mutated in approximately 6...
ORGANISM(S): Homo sapiens 
2016-08-22 | E-GEOD-85107 | biostudies-arrayexpress
GenomicsASXL1 Mutations Promote Myeloid Transformation Through Loss of PRC2-Mediated Gene Repression
Recurrent somatic ASXL1 mutations occur in patients with myelodysplasia (MDS), myeloproliferative neoplasms (MPN), and acute myeloid leukemia (AML), and are associated with adverse outcome. Despite the genetic and clinical data implicating ASXL1 mutations in myeloid malignancies, the mechanisms of t...
ORGANISM(S): Homo sapiens 
2012-08-21 | E-GEOD-38861 | biostudies-arrayexpress
TranscriptomicsDynamic single-cell imaging of direct reprogramming reveals an early specifying event
The study of induced pluripotency often relies on experimental approaches that average measurements across a large population of cells, the majority of which do not become pluripotent. Here we used high-resolution, time-lapse imaging to trace the reprogramming process over 2 weeks from single mouse ...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-21361 | biostudies-arrayexpress
TranscriptomicsDOT1L Inhibits SIRT1 and SUV39H1-Mediated H3K9 Modification to Maintain Gene Expression (array)
Methylation of histone 3 on lysine 79 (H3K79) is broadly associated with active gene expression in eukaryotes, and the H3K79 methyltransferase DOT1L is indispensable for specific leukemia subtypes like those with MLL-translocations. We found that suppression of the histone deacetylase SIRT1 rescued ...
ORGANISM(S): Mus musculus 
2015-03-30 | E-GEOD-61013 | biostudies-arrayexpress
ProteomicsMechanical confinement governs phenotypic plasticity in melanoma
Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes - proliferative versus invasive states. While it has long been hypothesised that such switching is triggered by external cues, the identity of these cues has remained elusive. Her...
ORGANISM(S): Homo sapiens (Human) 
2025-08-26 | PXD060265 | Pride
Lc-ms Hmgb2 Melanoma 
GenomicsH2A.Z landscapes and dual modifications in pluripotent and multipotent stem cells underlie complex genome regulatory functions
The histone variant H2A.Z has been implicated in nucleosome exchange, transcriptional activation and Polycomb repression. However, the relationships among these seemingly disparate functions remain obscure. We mapped H2A.Z genome-wide in mammalian ES cells and neural progenitors. H2A.Z is deposited ...
ORGANISM(S): Mus musculus 
2012-07-19 | E-GEOD-39237 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse ES cells, neural precursor cells and embryonic fibroblasts
Expression profiles for isogenic (129SvJae x C57BL/6) murine embryonic stem (ES) cells, neural precursors (NPC) obtained through in vitro differentiation of the ES cells, and embryonic fibroblasts (MEF) obtained at day 13.5. Experiment Overall Design: 3 replicates of wt ES cells, 3 replicates of wt...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-8024 | biostudies-arrayexpress
Proteomics,MultiomicsIdentification SETD1A-binding proteins by Co-IP MS
The dataset contains the gelLC MS analysis of immunoprecipitated complex from full-lenght and truncated SETD1A. The protein was ectopically expressed and the binders immunoprecipitated in cell transduced with the empty vector were analyzed as control.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-01 | MSV000080012 | MassIVE
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