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TranscriptomicsTranscription profiling of peripheral blood mononuclear cells taken from rheumatoid arthritis patients before and after treatment with Ethanercept (Enbrel)
Rheumatoid Arthritis patients were with Ethanercept (Enbrel), blocking the TNF alpha signalcascade by receptor mimicri. Peripheral blood samples were taken at 3 timepoints, before the first and 2 next drug injections after 3 and 6 days (t0, t1 (72h), t2 (144h)). Peripheral blood mononuclear cells we...
ORGANISM(S): Homo sapiens 
2010-04-22 | E-MTAB-11 | biostudies-arrayexpress
TranscriptomicsExpression data of multiple sclerosis patients receiving Interferon-beta therapy
The purpose of this study was to characterize the transcriptional effects induced by subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with relapsing-remitting form of multiple sclerosis (MS). By using Affymetrix DNA microarrays, we obtained genome-wide expression pr...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-24427 | biostudies-arrayexpress
no omics definedTranscription profiling by array of mouse Col8a1-Col8a2 deficient and wild type mesangial cells stimulated with TGF-beta1
Col8a1/Col8a2-deficient mesangial cells and wildtype cells are treated with TGFbeta-1 for 24h. This experiment was replicated once.
ORGANISM(S): Mus musculus 
2011-01-01 | E-MEXP-2658 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hep2 cells infected with Streptococcus pyogenes over time
Two biological replicate experiments were performed to estimate the bias of the gene expression pattern of infected and non-infected HEp-2 cells. Microarrays hybridized with RNA from 2 h of non-infected HEp-2 cells were used as reference chips for the comparison with microarrays hybridized with RNA ...
ORGANISM(S): Homo sapiens 
2005-06-30 | E-MEXP-271 | biostudies-arrayexpress
TranscriptomicsIdentification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
Discrimination of rheumatoid arthritis (RA) patients from patients with other inflammatory/degenerative joint diseases or healthy individuals purely on the basis of genes differentially expressed in high-throughput data has proven very difficult. Thus, the present study sought to achieve such discri...
ORGANISM(S): Homo sapiens 
2014-02-21 | E-GEOD-55235 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial samples from patients with osteoarthritis, rheumatoid arthritis vs controls treated with various drug regimes to characterise RA at the molecular level and to uncover key pathomechanisms
Rheumatoid arthritis (RA) is a chronic, inflammatory joint disease of unknown etiology and pronounced inter-patient heterogeneity. To characterize RA at the molecular level and to uncover key pathomechanisms, we performed whole-genome gene expression analyses. Synovial tissues from rheumatoid arthri...
ORGANISM(S): Homo sapiens 
2004-11-04 | E-GEOD-1919 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human synovial fibroblasts from rheumatoid arthritis and osteoarthritis patients
mRNA expression levels in synovial fibroblasts in 6 rheumatoid arthritis patients versus 6 osteoarthritis patients. Experiment Overall Design: Synovial tissue was obtained from open joint replacement surgery or Experiment Overall Design: arthroscopic synovectomy. Patients with RA or OA (n = 6 each...
ORGANISM(S): Homo sapiens 
2009-04-28 | E-GEOD-7669 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mpuse epididymal fat tissues-DU6/DU6i-DUKs/DBA
Pooled RNA samples were prepared for each of the four mouse strainsDU6, DU6i, DUKs, and DBA by epididymal fat tissues of 42 days old 20 male per lines. Pooling was used to reduce individual variability, which is high in outbred populations. For the hybridization of the tissue specific RNAs to the Ge...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1936 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) littermates
GOAL: Identification of genes and/or pathways involved in the pathogenesis of animal models of Rheumatoid Arthritis (RA). Total RNA samples were extracted from synovial fibroblast ex vivo cultures or whole joints (J), isolated from arthritic mice (197, DARE) and their corresponding normal (F1, wt) l...
ORGANISM(S): Mus musculus 
2005-06-30 | E-MEXP-255 | biostudies-arrayexpress
TranscriptomicsExpression data of multiple sclerosis patients receiving Interferon-beta therapy [miRNA-2_0]
The purpose of this study was to investigate the expression dynamics of mRNAs and microRNAs in response to subcutaneous IFN-beta-1b treatment (Betaferon, 250 µg every other day) in patients with clinically isolated syndrome (CIS) suggestive of multiple sclerosis (MS) or relapsing-remitting type of ...
ORGANISM(S): Homo sapiens 
2013-04-24 | E-GEOD-46282 | biostudies-arrayexpress
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