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ProteomicsPanorama of ancient metazoan macromolecular complexes: Drosophila melanogaster
By combining extensive biochemical fractionation with quantitative mass spectrometry, we directly examined the composition of soluble multiprotein complexes among diverse animal models. The project has been jointly supervised by Andrew Emili and Edward M. Marcotte. Project website: http://metazoa.m...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-06-17 | PXD002321 | Pride
Lc-msms Conservation Metazoan Biofractionation Across species 
ProteomicsPanorama of ancient metazoan macromolecular complexes: Saccharomyces cerevisiae
By combining extensive biochemical fractionation with quantitative mass spectrometry, we directly examined the composition of soluble multiprotein complexes among diverse animal models. The project has been jointly supervised by Andrew Emili and Edward M. Marcotte. Project website: http://metazoa.me...
ORGANISM(S): Saccharomyces cerevisiae W303 Saccharomyces cerevisiae (Baker's yeast) 
2015-06-29 | PXD002327 | Pride
Lc-msms Conservation Metazoan Biofractionation Across species 
ProteomicsPanorama of ancient metazoan macromolecular complexes: Sea urchin
By combining extensive biochemical fractionation with quantitative mass spectrometry, we directly examined the composition of soluble multiprotein complexes among diverse animal models. The project has been jointly supervised by Andrew Emili and Edward M. Marcotte. Project website: http://metazoa.me...
ORGANISM(S): Strongylocentrotus purpuratus (Purple sea urchin) 
2015-06-19 | PXD002325 | Pride
Lc-msms Conservation Metazoan Biofractionation Across species 
GenomicsThymic epithelia amplify noise in chromatin accessibility via p53 repression to impose immune tolerance [CUT&Run]
Thymic epithelia amplify noise in chromatin accessibility via p53 repression to impose immune tolerance [CUT&Run]
PRJNA1229619 | ENA
ProteomicsEndodermis-specific Receptor-like Kinase (ERK1) is required for the deposition of lignin in the Casparian strip in the root
The Casparian strip constitutes a physical diffusion barrier formed by the polar deposition of lignin in the root endodermis. The polar deposition of lignin is thought to be mediated by the scaffolding activity of membrane bound Casparian Strip domain proteins (CASPs) and the dirigent domain-contain...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2021-09-08 | PXD013861 | Pride
Arabidopsis Endodermis Time for coffee Erk1 Phosphorylation Root 
ProteomicsPhosphoproteomic Network Analysis in the Sea Urchin Strongylocentrotus purpuratus Reveals New Candidates in Egg Activation
Fertilization triggers a dynamic symphony of molecular transformations induced by a rapid rise in intracellular calcium. Most prominent are surface alterations, metabolic activation, cytoskeletal reorganization, and cell cycle reentry. While the activation process appears to be broadly evolutionaril...
ORGANISM(S): Strongylocentrotus purpuratus (Purple sea urchin) 
2015-08-04 | PXD002239 | Pride
Calcium / egg activation / network analysis / phosphoproteomics 
TranscriptomicsThermotoga maritima transcription during exponential and stationary phase growth on 1 and 5 g/l yeast extract
Although proteins and peptides encoded in small open reading frames (ORFs < 100 AA) in microbial genomes can play critical roles as toxins, bacteriocins, transcriptional regulators, signaling molecules, and chaperones, many such ORFs remain annotated as M-bM-^@M-^\hypothetical proteinsM-bM-^@M-^]. I...
ORGANISM(S): Thermotoga maritima 
2013-08-28 | E-GEOD-47072 | biostudies-arrayexpress
GenomicsChIP-seq of Klf2 in mouse embryonic stem cells (Serum/LIF and 2i)
The self-renewing pluripotent state was first captured in mouse embryonic stem cells (mESCs) over two decades ago. The standard condition requires the presence of serum and LIF, which provide growth promoting signals for cell expansion. However, there are pro-differentiation signals which destabiliz...
ORGANISM(S): Mus musculus 
2014-06-04 | E-MTAB-2365 | biostudies-arrayexpress
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (PBRM1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
2021-07-24 | PXD020554 | JPOST Repository
ProteomicsPBRM1-deficient PBAF complexes target de novo genomic loci to activate pro-survival genes in clear cell renal cell carcinoma (BRG1 dataset)
PBRM1 is lost in 40% of clear cell renal cell carcinomas (ccRCC) and the combined loss of VHL and PBRM1 drives ccRCC tumorigenesis. PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and despite its well-established role as a tumor suppressor, we have limited under...
ORGANISM(S): Homo Sapiens (human) 
2021-07-24 | PXD020553 | JPOST Repository
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