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TranscriptomicsThe role of the protein kinase-A pathway in the response to alkaline pH stress in yeast
Exposure of Saccharomyces cerevisiae to alkaline pH represents a stress condition that generates a compensatory reaction. Here we examine a possible role of the protein kinase-A (PKA) pathway in this response. The phenotypic analysis reveals that mutations that activate the PKA pathway (ira1 ira2, b...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-15 | E-GEOD-27925 | biostudies-arrayexpress
TranscriptomicsEffect of Ribavirin on Viral Kinetics and Liver Gene Expression in Chronic Hepatitis C
Background/Aims: Ribavirin improves treatment response to pegylated-interferon (PEG-IFN) in chronic hepatitis C but the mechanism remains controversial. We studied correlates of response and mechanism of action of ribavirin in treatment of hepatitis C. Methods: 70 treatment-naïve patients were rand...
ORGANISM(S): Homo sapiens 
2013-03-08 | E-GEOD-38663 | biostudies-arrayexpress
GenomicsChromatin organization in NPP-13 knockdown C. elegans embryos [seq]
C. elegans nuclear pore protein NPP-13 associates with small RNA genes transcribed by RNA Polymerase III. To test if the nuclear pore-chromatin interactions play a role in large-scale chromatin organization, we determined nuclear membrane-genome interactions and RNA Polymerase II localization in C. ...
ORGANISM(S): Caenorhabditis elegans 
2016-08-15 | E-GEOD-49903 | biostudies-arrayexpress
ProteomicsProteome-wide non-cleavable crosslink identification with MS Annika 3.0 reveals the structure of the C. elegans Box C/D complex
The field of crosslinking mass spectrometry has seen substantial advancements over the past decades, enabling the structural analysis of proteins and protein-complexes and serving as a powerful tool in protein-protein interaction studies. However, data analysis of large non-cleavable crosslink studi...
ORGANISM(S): Caenorhabditis elegans 
2024-12-19 | PXD055488 | Pride
Non-cleavable C. elegans Crosslinker Dsg Crosslink Crosslinking 
TranscriptomicsChip-chip analysis of C. glutamicum SigC
Bacteria modify expression of different types of terminal oxidase in response to oxygen availability. Corynebacterium glutamicum, a facultative anaerobic bacterium in Actinobacteria, possesses aa3-type cytochrome c oxidase and cytochrome bd-type quinol oxidase, the latter of which is induced upon ox...
ORGANISM(S): Corynebacterium glutamicum 
2016-08-22 | E-GEOD-72452 | biostudies-arrayexpress
UnknownAn updated inventory of sea slugs from Koh Tao, Thailand, with notes on their ecology and a dramatic biodiversity increase for Thai waters.
Not available
S-EPMC8208966 | biostudies-literature
Transcriptomicsc-Jun impedes somatic cell reprogramming by activating mesenchymal core regulators and suppressing pluripotent ones
The somatic cell fate can be converted to tumor or pluripotent ones by ectopic expression of transcription factors in vitro and in vivo. Many oncogenic transcription factors are known to mediate both fates as they share similar proliferative and metabolic properties. Paradoxically, we found c-Jun as...
ORGANISM(S): Mus musculus 
2015-06-10 | E-GEOD-50776 | biostudies-arrayexpress
UnknownDesigned NiMoC@C and NiFeMo2C@C core-shell nanoparticles for oxygen evolution in alkaline media.
Not available
S-EPMC10169681 | biostudies-literature
GenomicsIntegral nuclear pore proteins bind to Pol III genes and are required for Pol III transcript processing in C. elegans [seq]
Nuclear pores associate with active protein-coding genes in yeast and have been implicated in transcriptional regulation. Here, we show that in addition to transcriptional regulation, key components of C. elegans nuclear pores are required for processing of a subset of small nucleolar RNAs (snoRNAs)...
ORGANISM(S): Caenorhabditis elegans 
2013-09-05 | E-GEOD-42714 | biostudies-arrayexpress
GenomicsDevelopmental dynamics of C. elegans dosage compensation
In Caenorhabditis elegans, the dosage compensation complex (DCC) specifically binds to and represses transcription from both X chromosomes in hermaphrodites. The DCC is composed of an X-specific condensin complex that interacts with several proteins. During embryogenesis, DCC starts localizing to th...
ORGANISM(S): Caenorhabditis briggsae 
2015-11-09 | E-GEOD-67650 | biostudies-arrayexpress
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