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ProteomicsProteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells
Acute kidney injury is strongly associated with mortality in COVID-19 patients. However, host cell changes underlying infection of kidney cells with SARS-CoV-2 remain unknown and prevent understanding of the mechanisms leading to renal pathology. Here, we carried out extensive, dual-level proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-30 | PXD024398 | Pride
Meprod Tmd Tmt Sars-cov-2 Coronavirus Mers-cov Human 
ProteomicsClpP-deletion causes azoospermia, with meiosis-I delay and insufficient biosynthesis of spermatid factors, due to mitochondrial dysfunction with accumulation of Perrault proteins ERAL1, PEO1, and HARS2.
Human Perrault syndrome (PRLTS) is defined by autosomal recessive inheritance with primary ovarian insufficiency and early hearing loss. Most PRLTS disease proteins modulate mitochondrial transcription or translation. Among the genetic causes are ClpP mutations, which trigger also complete azoosperm...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD033388 | Pride
Meiosis-i  zygotene-pachytene  homologous recombination  h3k9ac  acetyl-tubulin  twinkle helicase  rmnd1  trna /rrna processing  cgas-sting signaling 
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