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TranscriptomicsCytokine stimulation systems approach demonstrates differences in innate and pro-inflammatory host responses between genetically distinct MERS-CoV isolates.
Background: The recent emergence of a novel coronavirus in the Middle East (designated MERS-CoV) is a reminder of the zoonotic potential of coronaviruses and the severe disease these etiologic agents can cause in humans. Clinical features of Middle East respiratory syndrome (MERS) include severe acu...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56677 | biostudies-arrayexpress
GenomicsBetacoronavirus 1 strain:Mers-cov
Mers-cov Genome sequencing and assembly
PRJNA387156 | ENA
ProteomicsComparison of N- and O-glycosylation on Spike Glycoprotein 1 of SARS-CoV-1 and MERS-CoV
Coronaviruses (CoVs) are enveloped pathogens causing multiple respiratory disorders in humans with varying severity. Spike protein is one of the major proteins expressed on coronavirus surface, which mediates coronavirus entry into host cells. Spike proteins are extensively glycosylated and the glyc...
ORGANISM(S): Middle East respiratory syndrome-related coronavirus Severe acute respiratory syndrome coronavirus 
2025-04-07 | PXD062150 | Pride
Glycosylation Sars-cov-1 Mers-cov 
ProteomicsProteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells
Acute kidney injury is strongly associated with mortality in COVID-19 patients. However, host cell changes underlying infection of kidney cells with SARS-CoV-2 remain unknown and prevent understanding of the mechanisms leading to renal pathology. Here, we carried out extensive, dual-level proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-30 | PXD024398 | Pride
Meprod Tmd Tmt Sars-cov-2 Coronavirus Mers-cov Human 
TranscriptomicsTranscriptional responses of Middle East respiratory syndrome coronavirus (MERS-CoV) in marmosets
The absence of a robust disease model currently hinders the evaluation of countermeasures for Middle East respiratory syndrome coronavirus (MERS-CoV). While a rhesus macaque model of MERS-CoV that results in mild-to-moderate disease has been utilized to describe the pathogenesis of this virus and fo...
ORGANISM(S): Callithrix jacchus 
2014-06-10 | E-GEOD-55023 | biostudies-arrayexpress
ProteomicsLC-MS/MS EThcD of MERS-CoV and SARS-CoV S N-linked glycopeptides from recombinant spike ectodomains and whole MERS virions
Recent outbreaks of severe acute respiratory syndrome and Middle-East respiratory syndrome along with the threat of a future coronavirus pandemic underscore the importance of finding ways to neutralize these viruses. The trimeric spike transmembrane glycoprotein S mediates entry into host cells and ...
ORGANISM(S): Severe Acute Respiratory Syndrome-related Coronavirus (ncbitaxon:694009) Middle East Respiratory Syndrome-related Coronavirus (ncbitaxon:1335626) 
2020-03-13 | MSV000085097 | MassIVE
TranscriptomicsInterferon and ribavirin treatment in a rhesus macaque model of novel Middle East respiratory syndrome coronavirus (MERS-CoV) infection (hCoV-EMC)
Microarray analysis of lungs (right lower lobe) on day 3 post-infection with MERS-CoV with and without treatment beginning 8 h post-infection with intravenous type I interferon (IFN) and ribavirin (RBV). Dosages are as follows: IFN a2b 5 million IU/kg s.c. q8, RBV loading dose 50mg/kg i.v.; RBV mai...
ORGANISM(S): Macaca mulatta 
2013-09-06 | E-GEOD-47957 | biostudies-arrayexpress
ProteomicsMass spectrometry data of identified proteins of MERS-CoV ORF4b interacting protein
Mass spectrometry data of identified proteins of MERS-CoV ORF4b protein
ORGANISM(S): Homo Sapiens 
2022-03-06 | PXD032092 |
ProteomicsMIB-MS analysis of MERS-CoV and SARS-COV-2 infected cells.
Host kinases play essential roles in the host cell cycle, innate immune signaling, the stress response to viral infection, and inflammation. Previous work has demonstrated coronaviruses specifically target kinase cascades to subvert host cell responses to infection and rely upon host kinase activity...
ORGANISM(S): Homo sapiens (Human) 
2023-08-01 | PXD040901 | Pride
Mib-ms  kinases  kinome  coronavirus  mers-cov  sars-cov-2  lfq quantitation  dda  lc-ms/ms. 
ProteomicsMass spectrometry data of identified proteins of MERS-CoV ORF3 interacting protein
Mass spectrometry data of identified proteins of MERS-CoV ORF3 protein
ORGANISM(S): Homo Sapiens Middle East Respiratory Syndrome-related Coronavirus 
2021-11-28 | PXD030024 |
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