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ProteomicsTranslation proteomics of OSCC CD44/CD36 sorted subpopulations
Metabolic flexibility is a common hallmark of aggressive and metastatic cancers. Here, we reveal that dynamic changes in mitochondrial translation rates drive the switch between glycolytic and mitochondrial energy production required for metastasis. We find that loss of 5-methylcytosine (m5C) in mit...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD021835 | Pride
Oscc Proteomics Meprod Translation 
UnknownFunctional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α.
Not available
S-EPMC7033560 | biostudies-literature
ProteomicsFunctional translatome proteomics reveal converging regulation by mTORC1 and eIF2α
Regulation of the translatome is essential during stress. However, the precise sets of translational targets regulated by the key translational stress responses –integrated stress response (ISR) and mTORC1 – remain elusive. We developed multiplexed enhanced protein dynamics (mePROD) proteomics, comb...
ORGANISM(S): Homo sapiens (Human) 
2019-12-06 | PXD014377 | Pride
Human Tmt Translation Pulsed silac 
ProteomicsFunctional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
Regulation of the translatome is essential during stress. However, the precise sets of translational targets regulated by the key translational stress responses –integrated stress response (ISR) and mTORC1 – remain elusive. We developed multiplexed enhanced protein dynamics (mePROD) proteomics, comb...
ORGANISM(S): Homo sapiens (Human) 
2019-12-09 | PXD015438 | Pride
Proteomics Tmt Psilac Translation 
ProteomicsHuman mitochondrial protein import proteomics LFQ
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-18 | PXD024054 | Pride
Meprod Mitochondrial import Lfq Human 
ProteomicsHuman mitochondrial protein import proteomics
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-18 | PXD022521 | Pride
Meprod Tmt Mitochondrial import Human Pulsed silac 
ProteomicsHuman mitochondrial protein import proteomics - Proteinase K control
Most mitochondrial proteins are encoded in the nucleus and require mitochondrial import after translation in the cytosol. A number of mutations in the mitochondrial protein import machinery have been shown to lead to human pathologies. However, a lack suitable tools to measure mitochondrial protein ...
ORGANISM(S): Homo sapiens (Human) 
2021-12-20 | PXD024066 | Pride
Meprod Tmd Tmt Mitochondrial protein import Human Dda 
ProteomicsProteomic landscape of SARS-CoV-2- and MERS-CoV-infected primary human renal epithelial cells
Acute kidney injury is strongly associated with mortality in COVID-19 patients. However, host cell changes underlying infection of kidney cells with SARS-CoV-2 remain unknown and prevent understanding of the mechanisms leading to renal pathology. Here, we carried out extensive, dual-level proteomic ...
ORGANISM(S): Homo sapiens (Human) 
2022-01-30 | PXD024398 | Pride
Meprod Tmd Tmt Sars-cov-2 Coronavirus Mers-cov Human 
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