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TranscriptomicsMonopolar attachment of sister kinetochores at meiosis I requires casein kinase 1.
The segregation of maternal centromeres away from the paternal ones during the first division of meiosis depends on the attachment of sister kinetochores to microtubules emanating from the same spindle pole. In budding yeast monopolar attachment requires the recruitment to kinetochores of a protein ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-4792 | biostudies-arrayexpress
TranscriptomicsScreening of genes involved in chromosome segregation in meiosis I
Prophase I of meiosis involves dynamic chromosome segregation processes including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes responsible for infertility or recur...
ORGANISM(S): Mus musculus 
2012-06-03 | E-GEOD-35734 | biostudies-arrayexpress
TranscriptomicsScreening of genes involved in chromosome segregation in meiosis I
Prophase I of male meiosis involves dynamic chromosome segregation processes during early spermatogenesis, including synapsis, meiotic recombination, and cohesion. Genetic defects in genes participating in these processes consistently cause reproduction failure in mice. To identify candidate genes r...
ORGANISM(S): Mus musculus 
2010-03-31 | E-GEOD-19532 | biostudies-arrayexpress
TranscriptomicsProtein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I
Segregation of homologous maternal and paternal centromeres to opposite poles during meiosis I depends on post-replicative crossing over between homologous non-sister chromatids, which creates chiasmata and therefore bivalent chromosomes. Destruction of sister chromatid cohesion along chromosome arm...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4791 | biostudies-arrayexpress
ProteomicsSpo13/MEIKIN ensures a two-division meiosis by preventing the activation of APC/CAma1 at meiosis I
Genome haploidization at meiosis depends on two consecutive nuclear divisions, which are controlled by an oscillatory system consisting of Cdk1-cyclin B and the APC/C bound to the Cdc20 activator. How the oscillator generates exactly two divisions has been unclear. We have studied this question in y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-09-03 | PXD044597 | Pride
Apc/c-ama1 / cyclin phosphorylation / meiotic exit / polo-like kinase / spo13/meikin / translational repressor 
ProteomicsPhosphoproteome dynamics at the transition from meiosis I to meiosis II
The proteome and phosphoproteome in meiosis from metaphase I to metaphase II after synchronisation using the GALpromoter-NDT80 block-release system are presented. The phosphoproteome dynamics are presented in two contexts: 1- in a wild-type context with 10 time points at 10min intervals 2- in a Cdc...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-06-16 | PXD043862 | Pride
Meiosis Phosphoproteome Cdk 
ProteomicsReductional meiosis I chromosome segregation is established by coordination of key meiotic kinases
Meiosis produces gametes through a specialised, two-step cell division, which is highly error-prone in humans. Reductional meiosis I, where maternal and paternal chromosomes (homologs) segregate, is followed by equational meiosis II, where sister chromatids separate. Uniquely during meiosis I, siste...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-13 | PXD012627 | Pride
Chromosome segregation Lc-ms Kinases Meiosis 
ProteomicsSelective dephosphorylation by PP2A-B55 directs the meiosis I - meiosis II transition in oocytes
Meiosis is a specialized cell cycle that requires sequential changes to the cell division machinery to facilitate changing functions. To define the mechanisms that enable the oocyte-to-embryo transition, we performed time-course proteomics in sea star oocytes from prophase I through the first embryo...
ORGANISM(S): Patiria Miniata (ncbitaxon:46514) 
2020-08-14 | MSV000085949 | MassIVE
TranscriptomicsMapping of cohesion factor association sites in S. cerevisiae - Meiosis I chromosome segregation is established through regulation of microtubule-kinetochore interactions.
During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain together. Determining how this unusual chromosome segregation behavior is estab...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-05 | E-GEOD-41339 | biostudies-arrayexpress
GenomicsThe SUN1-SPDYA interaction plays an essential role in meiosis prophase I
The SUN1-SPDYA interaction plays an essential role in meiosis prophase I
PRJNA648834 | ENA
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