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UnknownContinuous evolution of compact protein degradation tags regulated by selective molecular glues.
Conditional protein degradation tags (degrons) are usually >100 amino acids long or are triggered by small molecules with substantial off-target effects, thwarting their use as specific modulators of endogenous protein levels. We developed a phage-assisted continuous evolution platform for molecular...
S-EPMC11203266 | biostudies-literature
UnknownPhosphorylation-Inducing Molecules for Regulating Dynamic Cellular Processes.
Dynamic cellular processes often employ protein phosphorylation for rapid information transfer within and between cells. Phosphorylation-inducing chimeric small molecules (PHICS) have been developed for targeted protein phosphorylation by on-demand inducing a kinase-protein pairing. However, widespr...
S-EPMC12366445 | biostudies-literature
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD047593 | Pride
Degron Protein degradation Cereblon Phase-assisted evolution Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD047665 | Pride
Cereblon Phase assisted evolution Molecular glue Imid Protein degradation 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2026-08-29 | PXD044978 | Pride
Protein degradation Cereblon Evolution Mg-pace Zinc finger Molecular glues 
ProteomicsContinuous evolution of compact protein degradation tags regulated by selective cereblon molecular glues
Small molecule-triggered protein degradation tags (degrons) are powerful tools for biology, biotechnology, and therapeutics development. Commonly used degrons, however, are large protein domains (typically >100 amino acids) that cannot be easily or cleanly installed in endogenous protein-coding gene...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD044940 | Pride
Phage Cereblon Evolution Molecular glue Mg-pace Protein degradation 
UnknownProteolysis-targeting chimeras with reduced off-targets.
Proteolysis-targeting chimeras (PROTACs) are molecules that induce proximity between target proteins and E3 ligases triggering target protein degradation. Pomalidomide, a widely used E3 ligase recruiter in PROTACs, can independently degrade other proteins, including zinc-finger (ZF) proteins, with v...
S-EPMC10913580 | biostudies-literature
UnknownA general approach to identify cell-permeable and synthetic anti-CRISPR small molecules.
The need to control the activity and fidelity of CRISPR-associated nucleases has resulted in a demand for inhibitory anti-CRISPR molecules. The small-molecule inhibitor discovery platforms available at present are not generalizable to multiple nuclease classes, only target the initial step in the ca...
S-EPMC9891305 | biostudies-literature
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