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TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat 3 months old male Wistar animals by aorto-caval fistula reveals alterations in systemic substrate metabolism in rat volume-overload model of chronic heart failure
Abnormalities in metabolism of energetic substrates may play a role in progression of chronic heart failure (HF). The goal of the study was to examine the extent and mechanisms of metabolic alterations in rat model of chronic HF due to volume overload. Volume overload was induced in 3 months old mal...
ORGANISM(S): Rattus norvegicus 
2011-10-05 | E-MTAB-190 | biostudies-arrayexpress
TranscriptomicsNsaRS is a Cell-Envelope-Stress Sensing Two-Component System of Staphylococcus aureus
S. aureus possesses 16 two-component systems (TCS), two of which (GraRS & NsaRS) belong to the intramembrane-sensing histidine kinase (IM-HK) family, conserved within the firmicutes. NsaRS has recently been documented as being important for nisin-resistance in S. aureus. In this study we present a d...
ORGANISM(S): Staphylococcus aureus 
2011-05-16 | E-GEOD-27061 | biostudies-arrayexpress
UnknownIncreased Susceptibility of Humanized NSG Mice to Panton-Valentine Leukocidin and Staphylococcus aureus Skin Infection.
Not available
S-EPMC4664407 | biostudies-literature
ProteomicsDesmin knock-out cardiomyopathy: a heart on the verge of metabolic crisis
Background: Mutations of the desmin gene cause familial and sporadic cardiomyopathies and myopathies. Previous studies showed that both the lack of desmin and expression of mutated desmin negatively impact on number, structure and function mitochondria implying a metabolic dysfunction as disease pro...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-21 | PXD030938 | Pride
Metabolism Fatty acid Desmin Mitochondria Glucose Desminopathy Desmin knock-out Creatine kinase Cardiomyopathy Amino acid 
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