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UnknownMesenchymal MAPKAPK2/HSP27 drives intestinal carcinogenesis.
Not available
S-EPMC6004446 | biostudies-literature
ProteomicsRepurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.
Synovial Fibroblasts (SFs) are key pathogenic drivers in arthritis and their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models. TNF blockade has been efficacious for a large percentage of Rheumatoid Arthritis (RA) patients, although characterized by ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-06 | PXD036283 | Pride
Rheumatoid arthritis Amisulpride Repurposing Synovial fibroblasts Chemical proteomics Click-chemistry 
UnknownThe p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts.
Not available
S-EPMC5809454 | biostudies-literature
UnknownDifferent fibroblast subtypes propel spatially defined ileal inflammation through TNFR1 signalling in murine ileitis.
Not available
S-EPMC11953319 | biostudies-literature
TranscriptomicsTranscription profiling of brain from mice with multiple sclerosis, Alzheimers disease and permanent mid-cerebral artery occlusion from stroke to compare of gene expression changes characterizing these three different central nervous system pathologies
Three mouse models of human central nervous system pathologies were selected for analyzing gene expression changes compared to wild type normal brain. The selected models are: TgAPP23 for Alzheimerï¾’s disease (see Sturchler-Pierrat, C., Abramowski, D., Duke, M., Wiederhold, K.H., Mistl, C., Rothac...
ORGANISM(S): Mus musculus 
2008-07-12 | E-MTAB-1 | biostudies-arrayexpress
UnknownFibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity.
Not available
S-EPMC7610542 | biostudies-literature
TranscriptomicsIdentification of microRNAs association with Rheumatoid Arthritis Synovial Fibroblasts using the Human TNF Transgenic Mouse Model
OBJECTIVE: MicroRNAs (miRNAs, miRs), a class of small non-coding RNA molecules, are posttranscriptional regulators involved in a plethora of cellular functions and have been proposed as potential therapeutic targets in various diseases, including rheumatoid arthritis (RA). In this study, we sought t...
ORGANISM(S): Mus musculus 
2012-05-13 | E-GEOD-31667 | biostudies-arrayexpress
UnknownGenetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice.
Not available
S-EPMC6480274 | biostudies-literature
UnknownCombination of subtherapeutic anti-TNF dose with dasatinib restores clinical and molecular arthritogenic profiles better than standard anti-TNF treatment.
Not available
S-EPMC8063445 | biostudies-literature
UnknownSingle-cell multimodal analysis identifies common regulatory programs in synovial fibroblasts of rheumatoid arthritis patients and modeled TNF-driven arthritis.
Not available
S-EPMC9316748 | biostudies-literature
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