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ProteomicsRepurposing of Amisulpride, a known antipsychotic drug, to target synovial fibroblasts activation in arthritis.
Synovial Fibroblasts (SFs) are key pathogenic drivers in arthritis and their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models. TNF blockade has been efficacious for a large percentage of Rheumatoid Arthritis (RA) patients, although characterized by ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-06 | PXD036283 | Pride
Rheumatoid arthritis Amisulpride Repurposing Synovial fibroblasts Chemical proteomics Click-chemistry 
TranscriptomicsIdentification of microRNAs association with Rheumatoid Arthritis Synovial Fibroblasts using the Human TNF Transgenic Mouse Model
OBJECTIVE: MicroRNAs (miRNAs, miRs), a class of small non-coding RNA molecules, are posttranscriptional regulators involved in a plethora of cellular functions and have been proposed as potential therapeutic targets in various diseases, including rheumatoid arthritis (RA). In this study, we sought t...
ORGANISM(S): Mus musculus 
2012-05-13 | E-GEOD-31667 | biostudies-arrayexpress
TranscriptomicsExpression data from laser microdissected murine intestinal epithelial cells
Microarray analyses of laser microdissected murine intestinal epithelial cells under the control of maternal inflammation at 17.5 days post conception demonstrates that maternal inflammation differentially regulates 2174 (iWT) and 3345 (iARE) genes in fetal tissue, but these transcriptional profile...
ORGANISM(S): Mus musculus 
2014-05-05 | E-GEOD-44433 | biostudies-arrayexpress
UnknownInfection and inflammation stimulate expansion of CD74+ Paneth cell subset to regulate disease progression
Not available
S-SCDT-10_15252-EMBJ_2023113975 | biostudies-other
UnknownDevelopment and validation of a targeted gene sequencing panel for application to disparate cancers.
Not available
S-EPMC6864073 | biostudies-literature
UnknownParity and lactation induce T-cell-mediated breast cancer protection.
Not available
S-EPMC12779547 | biostudies-literature
UnknownCo-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset.
Not available
S-EPMC11393698 | biostudies-literature
UnknownThe impact of coding germline variants on contralateral breast cancer risk and survival.
Not available
S-EPMC10027471 | biostudies-literature
UnknownFANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women.
Not available
S-EPMC10172381 | biostudies-literature
UnknownCYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.
Not available
S-EPMC7884683 | biostudies-literature
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