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ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol requests ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD018952 | Pride
Signaling Tmt Cancer Calibrator Tyrosine phosphorylation 
ProteomicsComparison of Lung Cancer Proteome Profiles 3: DIA
The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues.
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD004684 | Pride
Human Brplc fractionation Discovery proteomics Lung cancer Lc-ms/ms 
ProteomicsComparison of Lung Cancer Proteome Profiles 2: TMT
The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues.
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD004683 | Pride
Human Brplc fractionation Discovery proteomics Lung cancer Lc-ms/ms 
ProteomicsComparison of Lung Cancer Proteome Profiles 1: Label Free Quantification
The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues.
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD004682 | Pride
Human Brplc fractionation Discovery proteomics Lung cancer Lc-ms/ms 
ProteomicsLowering Sample Requirements to Study Tyrosine Kinase Signaling using Phosphoproteomics with the TMT Calibrator Approach
Analysis of tyrosine kinase signaling is critical for the development of targeted cancer therapy. Currently, immunoprecipitation (IP) of phosphotyrosine (pY) peptides prior to liquid chromatography-tandem mass spectrometry (LC-MS/MS) is used to profile kinase substrates. A typical protocol request...
ORGANISM(S): Homo sapiens (Human) 
2020-07-29 | PXD019764 | Pride
Signaling Phosphotyrosine Label free quantification Lung cancer Lc-ms/ms 
ProteomicsComparison of Targeted MS Methods in Activity-Based Protein Profiling 1: DDA
To examine the different mass spectrometry approaches to monitoring kinases after enrichment with desthiobiotinylating probes for activity-based protein profiling (ABPP), two experiments were performed with H1993 lung cancer cells. First, cell lysates were pre-treated with DMSO vehicle, dasatinib, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006095 | Pride
Dda Activity-based protein profiling Dia Prm Srm/mrm Lung cancer 
ProteomicsComparison of Targeted MS Methods in Activity-Based Protein Profiling 2: DIA
To examine the different mass spectrometry approaches to monitoring kinases after enrichment with desthiobiotinylating probes for activity-based protein profiling (ABPP), two experiments were performed with H1993 lung cancer cells. First, cell lysates were pre-treated with DMSO vehicle, dasatinib, ...
ORGANISM(S): Homo sapiens (Human) 
2017-11-27 | PXD006096 | Pride
Dda Activity-based protein profiling Dia Prm Srm/mrm Lung cancer 
ProteomicsComparison of Lung Cancer Proteome Profiles 4: DDA
The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues. This additional single sample LC-MS/MS analysis with data depend...
ORGANISM(S): Homo sapiens (Human) 
2017-02-16 | PXD005733 | Pride
Data dependent acquisition Lung cancer Discovery proteomics Lc-ms/ms Single sample analysis 
ProteomicsComparison of Lung Cancer Proteome Profiles 1: Label Free Quantification
The goal of this project is to compare label free quantification, chemical labeling with tandem mass tags, and data independent acquisition discovery proteomics approaches using lung squamous cell carcinomas and adjacent lung tissues.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-27 | MSV000080685 | MassIVE
ProteomicsTargeted Proteomics of Lung Squamous Cell Carcinomas
To address the complexity of cancer, liquid chromatography-multiple reaction monitoring mass spectrometry (LC-MRM) panels provide the capability to quantify clinical biomarkers and emerging protein markers to establish the context of tumor phenotypes that provide highly relevant supporting informati...
ORGANISM(S): Homo Sapiens 
PXD040680 | panorama
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