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MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
UnknownPChopper: high throughput peptide prediction for MRM/SRM transition design.
Not available
S-EPMC3230909 | biostudies-literature
ProteomicsHuman tissue microsomed by MRM, MRMHR and SWATH
The purpose of the present study was to examine simultaneously the absolute protein amounts of 152 membrane and membrane-associated proteins, including 30 metabolizing enzymes and 107 transporters, in pooled microsomal fractions of human liver, kidney and intestine by means of SWATH-MS with stable i...
ORGANISM(S): Homo Sapiens (human) 
2018-01-01 | PXD008265 | JPOST Repository
ProteomicsHemoglobin alpha-like chain subunit mu (HBM) is expressed during ontogeny and is elevated in alpha thalassemias
Background: Alpha and beta-like globin chains are encoded by gene clusters on chromosomes 16 and 11, respectively, with controlled expression patterns through development and childhood into adulthood. The alpha gene cluster contains genes such as HBA1, HBA2, HBZ and HBM. HBM was initially thought to...
ORGANISM(S): Homo sapiens (Human) 
2026-04-27 | PXD064022 | Pride
Hemoglobinopathy Protein Hematopoiesis thalassemia Translation 
ProteomicsQuantitative proteome analysis of hepatocellular carcinoma tissue
Hepatocellular carcinoma (HCC) is one of the most aggressive tumors and the treatment outcome of this disease is improved when the cancer is diagnosed at early stages. This requires biomarkers allowing for an accurate and early tumor diagnosis. To identify potential markers for such applications we ...
ORGANISM(S): Homo sapiens (Human) 
2016-04-13 | PXD002171 | Pride
Human Srm Tissue Label-free proteomics Hepatocellular carcinoma Bimarkers Mrm Multiple reaction monitoring Early diagnosis biomarker Versican. Targeted proteomics Selected reaction monitoring 
ProteomicsIdentification and Quantification of Human Relaxin Proteins by Immunoaffinity-Mass Spectrometry
We developed immunoaffinity-selected reaction monitoring assays for the measurment of human relaxin-1 and relaxin-2 proteins in biological and clinical samples.
ORGANISM(S): Homo sapiens (Human) 
2024-07-04 | PXD051230 | Pride
Relaxin h2 Relaxin h1 Rel1_human Mass spectrometry Rln2 Prostate Rln1 Immunoaffinity Rel2_human Maternal serum Enzyme-linked immunosorbent assay 
UnknownSelected reaction monitoring (SRM) mass spectrometry without isotope labeling can be used for rapid protein quantification.
Not available
S-EPMC4121859 | biostudies-literature
Genomics
Microbial community analysis in soil based on 16S rRNA gene sequencing
PRJNA1271745 | ENA
OtherDiscovery of colorectal cancer biomarker candidates by membrane proteomic analysisand subsequent verification using selected reaction monitoring and tissue microarrayanalysis
Data from ProteomeXchange, PXD ID: PXD000851. File: iTRAQ3.msf.mgf. Published as part of Mol Cell Proteomics. 2014 Mar 31 . From the Abstract: {{i}} We here performed a quantitative proteomic analysis of membrane fractions from colorectal cancer tissue to discover biomarker candidates, and then ext...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210027051 | GPMDB
Resource Reanalysis 
ProteomicsVaginal secretory proteome dynamically changes across the early and mid-trimesters of pregnancy
This study investigates the dynamic alterations in high vaginal fluid (HVF) proteome and its correlation with physiological changes during progression of term pregnancy. The HVF samples were collected at three time points as defined as V1 (6-12 weeks), V2 (18-20 weeks) and V3 (26-28 weeks) and SWAT...
ORGANISM(S): Homo sapiens (Human) 
2021-01-28 | PXD021811 | Pride
Pregnancy Human vaginal fluid Longitudinal study Mrm Swath ms 
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