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TranscriptomicsLongitudinal clonal IgG cross-reactivity profiles of coronavirus-specific B-cells in COVID-19 patients
We investigated the kinetics, breadth, magnitude, and level of cross-reactivity of IgG antibodies against SARS-CoV-2 and heterologous seasonal (HCoV-NL63, -229E, -OC43 and -HKU1) and epidemic coronaviruses (SARS-CoV, hCoV-MERS) at the clonal level in patients with mild or severe COVID-19 as well as ...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12161 | biostudies-arrayexpress
ProteomicsGRASPing experience-dependent protein expression signatures enriched for hippocampal engram cell synapses
Enhanced synaptic wiring onto sparsely distributed memory engram cells supports contextual memory storage and recall, with negative-valence memories exhibiting greater salience. Protein-level adaptations of input-specific synaptic connectivity onto hippocampal CA1 engram cells, however, remains larg...
ORGANISM(S): Mus musculus (Mouse) 
2026-03-24 | PXD054892 | Pride
UnknownPrimary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk-Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity.
Not available
S-EPMC5853962 | biostudies-literature
UnknownPulmonary lesions following inoculation with the SARS-CoV-2 Omicron BA.1 (B.1.1.529) variant in Syrian golden hamsters.
Not available
S-EPMC9295819 | biostudies-literature
UnknownTracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2 with grinch.
Not available
S-EPMC8176267 | biostudies-literature
GenomicsMajor Depression: Stage 1 Genomewide Association in Population-Based Samples

Identification of genomic regions that confer susceptibility to or protection from major depressive disorder (MDD) via genomewide association.

Consent groups and participant set

  • Psychiatric and Related Somatic Conditions (PRSC): 3741 (1821 cases, 1822 contro...
phs000020.v2.p1 | EGA
ProteomicsMultimodal Proteomics reveals dysregulated secretion and ECM remodeling in schizophrenia patient iPSC-derived astrocytes
Astrocytes are increasingly implicated in the pathophysiology of schizophrenia (SCZ), yet how astrocytic dysfunction contributes to disease-relevant neuronal abnormalities remains unclear. Here, we use mass spectrometry–based proteomics to profile lysates (proteome) and secreted (secretome) proteins...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD075039 | Pride
Astrocytes Proteomics Ipsc Schizophrenia Protein secretion 
ProteomicsMS-DAP platform for label-free proteomics uncovers optimal workflows in benchmark datasets and increased sensitivity in analysis of Alzheimer's biomarker data
In the rapidly moving proteomics field, a diverse patchwork of algorithms for data normalization and differential expression analysis is used by the community. We generated an all-inclusive mass spectrometry downstream analysis pipeline (MS-DAP) that integrates many algorithms for normalization and ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-03-10 | PXD036134 | Pride
Alzheimer’s disease Proteomics Software Benchmarking Bioinformatics 
ProteomicsHuman brain prefrontal cortex proteomics identifies compromised energy metabolism and neuronal function in Schizophrenia
Understanding the pathophysiological substrates of schizophrenia is a major challenge for current neuropsychiatric research. As part of a set of multi-omics experiments, we performed an extensive case-control proteomics study on 192 post-mortem tissue sections from prefrontal cortex from 96 individu...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD058441 | Pride
UnknownPicosecond optospintronic tunnel junctions
Not available
S-EPMC9214493 | biostudies-literature
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