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ProteomicsGlycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis
Liver fibrosis is characterized by the activation of perivascular hepatic stellate cells (HSCs), the release of fibrogenic nano-sized extracellular vesicles (EVs) and increased HSC glycolysis. Nevertheless, how glycolysis in HSCs coordinates fibrosis amplification through tissue zone-specific pathwa...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2024-05-16 | PXD050337 | Pride
Extracellular vesicles Glycolysis Spatial transcriptomics Liver fibrosis Hepatic stellate cells 
ProteomicsWith no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1
Liver fibrosis and cirrhosis are major global health burdens with limited treatments. Activated hepatic stellate cells (HSCs) drive fibrosis through increased proliferation, migration, collagen deposition and glycolysis. The aim of this study is to elucidate the signaling events that lead to enhance...
ORGANISM(S): Homo sapiens (Human) 
2026-08-13 | PXD078687 | Pride
Liver fibrosis. Chemical genetics Wnk1 Glucose metabolism Tpi1 Hepatic stellate cells 
ProteomicsHuman hepatic stellate cell-derived extracellular vesicles LC-MSMS
Activation and migration of hepatic stellate cells (HSCs) followed by matrix deposition are characteristics of liver fibrosis. Several studies have shown the importance of hepatocyte and endothelial cell-derived extracellular vesicles (EVs) in liver pathobiology. However, less is known about the rol...
ORGANISM(S): Homo sapiens (Human) 
2018-10-18 | PXD007258 | Pride
Lc-msms Hepatic stellate cells Extracellular vesicles Liver 
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